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. 2005 Jan;6(1):57-64.
doi: 10.1038/ni1142. Epub 2004 Nov 28.

Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection (VSports)

Regine Gläser  1 , Jürgen Harder, Hans Lange, Joachim Bartels, Enno Christophers, Jens-Michael Schröder
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Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection

Regine Gläser (VSports注册入口) et al. Nat Immunol. 2005 Jan.

"V体育ios版" Abstract

Human healthy skin is continuously exposed to bacteria, but is particularly resistant to the common gut bacterium Escherichia coli VSports手机版. We show here that keratinocytes secrete, as the main E. coli-killing compound, the S100 protein psoriasin in vitro and in vivo in a site-dependent way. In vivo treatment of human skin with antibodies to psoriasin inhibited its E. coli-killing properties. Psoriasin was induced in keratinocytes in vitro and in vivo by E. coli, indicating that its focal expression in skin may derive from local microbial induction. Zn(2+)-saturated psoriasin showed diminished antimicrobial activity, suggesting that Zn(2+) sequestration could be a possible antimicrobial mechanism. Thus, psoriasin may be key to the resistance of skin against E. coli. .

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