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. 2002 Oct;1(1):40-6.
doi: 10.1046/j.1474-9728.2002.00004.x.

VSports在线直播 - Mitochondrial dysfunction leads to telomere attrition and genomic instability

Lin Liu  1 , James R Trimarchi, Peter J S Smith, David L Keefe
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Mitochondrial dysfunction leads to telomere attrition and genomic instability (VSports注册入口)

Lin Liu et al. Aging Cell. 2002 Oct.
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"V体育平台登录" Abstract

Mitochondrial dysfunction and oxidative stress have been implicated in cellular senescence, apoptosis, aging and aging-associated pathologies. Telomere shortening and genomic instability have also been associated with replicative senescence, aging and cancer. Here we show that mitochondrial dysfunction leads to telomere attrition, telomere loss, and chromosome fusion and breakage, accompanied by apoptosis VSports手机版. An antioxidant prevented telomere loss and genomic instability in cells with dysfunctional mitochondria, suggesting that reactive oxygen species are mediators linking mitochondrial dysfunction and genomic instability. Further, nuclear transfer protected genomes from telomere dysfunction and promoted cell survival by reconstitution with functional mitochondria. This work links mitochondrial dysfunction and genomic instability and may provide new therapeutic strategies to combat certain mitochondrial and aging-associated pathologies. .

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