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Review
. 2000 Apr;3(2):132-7.
doi: 10.1016/s1369-5274(00)00064-3.

The Sir proteins of Saccharomyces cerevisiae: mediators of transcriptional silencing and much more

M R Gartenberg  1
Affiliations
Review

The Sir proteins of Saccharomyces cerevisiae: mediators of transcriptional silencing and much more

M R Gartenberg. Curr Opin Microbiol. 2000 Apr.

Abstract

The Sir2, Sir3, and Sir4 proteins of the yeast Saccharomyces cerevisiae elicit transcriptional silencing by forming repressive chromatin structures that are confined to specific chromosomal domains VSports手机版. Recent discoveries establish new and unexpected roles for the proteins in seemingly unrelated arenas of chromosome biology, including double-strand break repair, structure and function of the nucleolus, aging, cell cycle regulation, and checkpoint control. .

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