These reference sequences exist independently of genome builds VSports. Explain.

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above VSports app下载. .

Genomic

1. NG_012005.3 RefSeqGene

   Range

   914068..1139803

   Download

   "V体育安卓版" GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. NM_001159995 V体育官网. 3 → NP_001153467. 1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1c.

   Status: REVIEWED

   Description

   Transcript Variant: This variant (HRG-beta1c), which uses the type IV promoter, contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also lacks an in-frame exon in the central coding region, compared to variant HRG-beta1. The resulting isoform (HRG-beta1c, also known as type IV fetal C beta 1a or fetal b IV-beta 1a) has a distinct N-terminus, lacks an internal segment, and is shorter than isoform HRG-beta1.

   Source sequence(s)

   AC113209, CA429204, DA805080, EF517297, GQ983557, M94166

   Consensus CDS

   CCDS94272.1

   UniProtKB/TrEMBL

   A0A494C1F8, E3SFM9

   Related

   ENSP00000499008.1, ENST00000652698.1

   Conserved Domains (4) summary

   cd05895
   Location:32 → 106

   Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

   smart00410
   Location:22 → 108

   IG_like; Immunoglobulin like

   pfam00008
   Location:152 → 182

   EGF; EGF-like domain

   pfam02158
   Location:202 → 595

   Neuregulin; Neuregulin family

2. "VSports在线直播" NM_001159996. 3 → NP_001153468. 1  pro-neuregulin-1, membrane-bound isoform isoform ndf43c VSports手机版.

   See identical proteins and their annotated locations for NP_001153468.1

   Status: REVIEWED

   Description

   Transcript Variant: This variant (ndf43c), which uses the type VI promoter, lacks multiple 5' exons but contains an alternate 5' terminal exon, and it also lacks two in-frame exons in the central coding region and includes an additional exon that results in an alternate 3' coding region, compared to variant HRG-beta1. The resulting isoform (ndf43c, also known as ndf43) has distinct N- and C-termini, lacks an internal segment, and is shorter than isoform HRG-beta1.

   Source sequence(s)

   AC113209, AK293240, BC144446, CA429204, DA805080, DC425692

   Consensus CDS

   CCDS75727.1

   UniProtKB/TrEMBL

   B7Z1D7, E5RHP6

   Related

   ENSP00000430862.2, ENST00000522402.6

   Conserved Domains (3) summary

   PHA03099
   Location:28 → 120

   PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

   cd00054
   Location:36 → 68

   EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

   pfam02158
   Location:113 → 270

   Neuregulin; Neuregulin family

3. NM_001159999.3 → NP_001153471.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1b

   Status: REVIEWED

   Description

   Transcript Variant: This variant (HRG-beta1b), which uses the type IV promoter, contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, compared to variant HRG-beta1. The resulting isoform (HRG-beta1b, also known as type IV fetal B beta 1a) has a distinct N-terminus and is shorter than isoform HRG-beta1.

   Source sequence(s)

   AC113209, CA429204, CN603652, DA805080, EF517296, GQ983557, M94165, U02328

   Consensus CDS

   CCDS94271.1

   UniProtKB/TrEMBL

   A0A494C1F5, E3SFM9

   Related

   ENSP00000499045.1, ENST00000650866.1

   Conserved Domains (4) summary

   cd05895
   Location:32 → 106

   Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

   smart00410
   Location:22 → 108

   IG_like; Immunoglobulin like

   pfam00008
   Location:169 → 199

   EGF; EGF-like domain

   pfam02158
   Location:219 → 612

   Neuregulin; Neuregulin family

4. NM_001160001.3 (VSports手机版) → NP_001153473.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1d

   Status: REVIEWED

   Description

   Transcript Variant: This variant (HRG-beta1d), which uses the type IV promoter, contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also lacks two in-frame exons in the central coding region, compared to variant HRG-beta1. The resulting isoform (HRG-beta1d, also known as IV-beta 1a or type IV fetal A beta 1a) has a distinct N-terminus, lacks an internal segment, and is shorter than isoform HRG-beta1.

   Source sequence(s)

   AC113209, CA429204, CN603654, DA805080, EF372273, GQ983557, M94165

   Consensus CDS

   CCDS55218.1

   UniProtKB/TrEMBL

   E3SFM9

   Related

   ENSP00000429582.1, ENST00000519301.6

   Conserved Domains (4) summary

   cd05895
   Location:32 → 106

   Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

   smart00410
   Location:22 → 108

   IG_like; Immunoglobulin like

   pfam00008
   Location:135 → 165

   EGF; EGF-like domain

   pfam02158
   Location:185 → 578

   Neuregulin; Neuregulin family

5. NM_001160002.2 → NP_001153474.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma2

   Status: REVIEWED

   Description

   Transcript Variant: This variant (HRG-gamma2), which uses the type I promoter, lacks an internal in-frame exon and multiple 3' exons, but contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-gamma2, also known as gamma protein isoform 1) lacks an internal segment, has a distinct C-terminus, and is shorter than isoform HRG-beta1.

   Source sequence(s)

   AC083977, AC103675, EU363508

   UniProtKB/TrEMBL

   B0FYA7

   Conserved Domains (2) summary

   smart00410
   Location:43 → 129

   IG_like; Immunoglobulin like

   cl11960
   Location:53 → 127

   Ig; Immunoglobulin domain

6. VSports在线直播 - NM_001160004.3 → NP_001153476.1  pro-neuregulin-1, membrane-bound isoform isoform ndf43b

   See identical proteins and their annotated locations for NP_001153476.1

   Status: REVIEWED

   Description

   Transcript Variant: This variant (ndf43b), which uses the type I promoter, lacks an alternate in-frame exon in the central coding region, and contains an additional exon that results in an alternate 3' coding region, compared to variant HRG-beta1. The resulting isoform (ndf43b, also known as ndf43-beta2) lacks an internal segment, has a distinct C-terminus, and is shorter than isoform HRG-beta1.

   Source sequence(s)

   AC083977, AC113209, BC144446, CA429204, DA805080, EU363510

   Consensus CDS

   CCDS94273.1

   UniProtKB/TrEMBL

   A0A494C0K4, B0FYA9

   Related

   ENSP00000498583.1, ENST00000650980.1

   Conserved Domains (3) summary

   cd05895
   Location:53 → 127

   Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

   pfam02158
   Location:232 → 421

   Neuregulin; Neuregulin family

   cl28647
   Location:182 → 271

   PHA02887; EGF-like protein; Provisional

7. NM_001160005.2 → NP_001153477.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta3b

   See identical proteins and their annotated locations for NP_001153477.1

   Status: REVIEWED

   Description

   Transcript Variant: This variant (HRG-beta3b), which uses the type I promoter, lacks two internal in-frame exons and multiple 3' exons, but contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-beta3b, also known as HRG-beta 3 protein isoform) lacks an internal segment, has a distinct C-terminus, and is shorter than isoform HRG-beta1.

   Source sequence(s)

   AC083977, EU359055, M94168

   Consensus CDS

   CCDS94275.1

   UniProtKB/TrEMBL

   A0A494C114, B0FWZ3

   Related

   ENSP00000498833.1, ENST00000650967.1

   Conserved Domains (2) summary

   smart00410
   Location:43 → 129

   IG_like; Immunoglobulin like

   cl11960
   Location:53 → 127

   Ig; Immunoglobulin domain

8. NM_001160007.2 → NP_001153479.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma3

   Status: REVIEWED

   Description

   Transcript Variant: This variant (HRG-gamma3), which uses the type I promoter, lacks two internal in-frame exons and multiple 3' exons, but contains an alternate 3' terminal exon that results in an early stop codon and an alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-gamma3, also known as gamma protein isoform 2) lacks an internal segment and is shorter at the C-terminus, compared to isoform HRG-beta1.

   Source sequence(s)

   AC083977, AC103675, EU363509

   UniProtKB/TrEMBL

   B0FYA8

   Conserved Domains (2) summary

   cd00096
   Location:37 → 43

   Ig; putative Ig strand A [structural motif]

   cl11960
   Location:37 → 129

   Ig; Immunoglobulin domain

9. NM_001160008.2 → NP_001153480.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta2b

   Status: REVIEWED

   Description

   Transcript Variant: This variant (HRG-beta2b), which uses the type I promoter, lacks an alternate in-frame exon in the central coding region, and it also contains alternate 3' exon structure resulting an in early stop codon and alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-beta2b) lacks an internal segment and is shorter at the C-terminus, compared to isoform HRG-beta1.

   Source sequence(s)

   AC113209, AK097005, AK298132, BC006492, BQ018711

   Consensus CDS

   CCDS55219.1

   UniProtKB/TrEMBL

   B0FYA9

   Related

   ENSP00000430120.1, ENST00000523079.5

   Conserved Domains (3) summary

   cd05895
   Location:53 → 127

   Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

   pfam02158
   Location:232 → 420

   Neuregulin; Neuregulin family

   cl28647
   Location:182 → 271

   PHA02887; EGF-like protein; Provisional

10. NM_001322197.2 → NP_001309126.1  pro-neuregulin-1, membrane-bound isoform isoform VI-1

    Status: REVIEWED

    Description

    Transcript Variant: This variant (VI-1), which uses the type VI promoter, lacks multiple 5' exons but contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also lacks an in-frame exon in the central coding region, compared to variant HRG-beta1. The resulting isoform (VI-1) has a distinct N-terminus, lacks an internal segment, and is shorter than isoform HRG-beta1.

    Source sequence(s)

    AC113209, AK293270, CA429204, CN603661

    UniProtKB/TrEMBL

    B7Z1E3, E3SFM9

    Conserved Domains (2) summary

    PHA03099
    Location:28 → 117

    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

    pfam02158
    Location:78 → 471

    Neuregulin; Neuregulin family

11. V体育ios版 - NM_001322201.2 → NP_001309130.1  pro-neuregulin-1, membrane-bound isoform isoform a

    Status: REVIEWED

    Description

    Transcript Variant: This variant (fetal-a-IV-1), which uses the type IV promoter, contains an alternate 5' terminal exon and lacks three internal exons, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant HRG-beta1. The resulting isoform (a) is shorter at the N-terminus, compared to isoform HRG-beta1. Both variants fetal-a-IV-1 and fetal-c-IV-2 encode isoform a.

    Source sequence(s)

    AC083977, AC103675, AC113209, CA429204, EF372275, GQ983557

    UniProtKB/TrEMBL

    A5YAK6, E3SFM9

    Conserved Domains (1) summary

    pfam02158
    Location:1 → 370

    Neuregulin; Neuregulin family

12. NM_001322202.2 → NP_001309131.1  pro-neuregulin-1, membrane-bound isoform isoform a

    Status: REVIEWED

    Description

    Transcript Variant: This variant (fetal-c-IV-2), which uses the type IV promoter, contains an alternate 5' terminal exon and lacks four internal exons, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The resulting isoform (a) is shorter at the N-terminus, compared to isoform HRG-beta1. Both variants fetal-a-IV-1 and fetal-c-IV-2 encode isoform a.

    Source sequence(s)

    AC103675, AC113209, CA429204, EF372277, GQ983557

    UniProtKB/TrEMBL

    A5YAK8, E3SFM9

    Conserved Domains (1) summary

    pfam02158
    Location:1 → 370

    Neuregulin; Neuregulin family

13. NM_001322205.2 → NP_001309134.1  pro-neuregulin-1, membrane-bound isoform isoform NRG-III-beta1a

    Status: REVIEWED

    Description

    Transcript Variant: This variant (NRG-III-beta1a), which uses the type III promoter, lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant HRG-beta1. The resulting isoform (NRG-III-beta1a, also known as nARIAbeta1a or CRD-NRGbeta1a) has a distinct N-terminus and is longer than isoform HRG-beta1.

    Source sequence(s)

    AC103675, AC113209, AK289927, CA429204, EF517295

    Consensus CDS

    CCDS94277.1

    UniProtKB/TrEMBL

    A0A494C0Q4

    Related

    ENSP00000498646.1, ENST00000652592.1

    Conserved Domains (2) summary

    PHA02887
    Location:236 → 279

    PHA02887; EGF-like protein; Provisional

    pfam02158
    Location:295 → 688

    Neuregulin; Neuregulin family

14. NM_001322206.2 → NP_001309135.1  pro-neuregulin-1, membrane-bound isoform isoform III-2

    Status: REVIEWED

    Description

    Transcript Variant: This variant (III-2), which uses the type III promoter, lacks several 5' exons but contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also includes an additional exon that results in an alternate 3' coding region, compared to variant HRG-beta1. The resulting isoform (III-2) has distinct N- and C-termini and is shorter than isoform HRG-beta1.

    Source sequence(s)

    AC113209, AK289927, BC144446, CA429204, M94166

    Consensus CDS

    CCDS94276.1

    UniProtKB/TrEMBL

    A0A494C0L9

    Related

    ENSP00000498590.1, ENST00000651333.2

    Conserved Domains (2) summary

    PHA02887
    Location:236 → 279

    PHA02887; EGF-like protein; Provisional

    pfam02158
    Location:295 → 484

    Neuregulin; Neuregulin family

15. "V体育2025版" NM_001322207.2 → NP_001309136.1  pro-neuregulin-1, membrane-bound isoform isoform III-3

    Status: REVIEWED

    Description

    Transcript Variant: This variant (III-3), which uses the type III promoter, lacks several 5' exons but contains an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and it also contains an alternate 3' terminal exon that results in an early stop codon, compared to variant HRG-beta1. The resulting isoform (III-3) has distinct N- and C-termini and is shorter than isoform HRG-beta1.

    Source sequence(s)

    AC113209, AK289927, AK298132, BC144446, BQ018711, M94166

    Consensus CDS

    CCDS94278.1

    UniProtKB/TrEMBL

    A0A494C1B5

    Related

    ENSP00000498946.1, ENST00000650819.1

    Conserved Domains (2) summary

    PHA02887
    Location:236 → 279

    PHA02887; EGF-like protein; Provisional

    pfam02158
    Location:295 → 483

    Neuregulin; Neuregulin family

16. VSports注册入口 - NM_004495.4 → NP_004486.2  pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma

    See identical proteins and their annotated locations for NP_004486.2

    Status: REVIEWED

    Description

    Transcript Variant: This variant (HRG-gamma), which uses the type I promoter, lacks multiple 3' exons but contains an alternate 3' terminal exon that results in an early stop codon, compared to variant HRG-beta1. The resulting isoform (HRG-gamma) is shorter at the C-terminus, compared to isoform HRG-beta1.

    Source sequence(s)

    AC083977, AC103675, BC144446

    UniProtKB/TrEMBL

    B5BU95, Q7RTW5

    Related

    ENST00000651807.1

    Conserved Domains (2) summary

    smart00410
    Location:43 → 129

    IG_like; Immunoglobulin like

    cl11960
    Location:53 → 127

    Ig; Immunoglobulin domain

17. NM_013956.5 → NP_039250.2  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1

    See identical proteins and their annotated locations for NP_039250.2

    Status: REVIEWED

    Description

    Transcript Variant: This variant (HRG-beta1), which uses the type I promoter, encodes isoform HRG-beta1 (also known as NDF-beta1a or HRG-beta1a).

    Source sequence(s)

    AC113209, AK097005, AK298132, BC006492, BC144446, CA429204, DA805080, M94166

    Consensus CDS

    CCDS6083.1

    UniProtKB/TrEMBL

    Q7RTW4

    Related

    ENSP00000287842.4, ENST00000287842.7

    Conserved Domains (4) summary

    cd05895
    Location:53 → 127

    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

    smart00410
    Location:43 → 129

    IG_like; Immunoglobulin like

    pfam00008
    Location:190 → 220

    EGF; EGF-like domain

    pfam02158
    Location:240 → 633

    Neuregulin; Neuregulin family

18. NM_013957.5 → NP_039251.2  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta2

    See identical proteins and their annotated locations for NP_039251.2

    Status: REVIEWED

    Description

    Transcript Variant: This variant (HRG-beta2), which uses the type I promoter, lacks an alternate in-frame exon in the central coding region, compared to variant HRG-beta1, resulting in an isoform (HRG-beta2) that is shorter than isoform HRG-beta1.

    Source sequence(s)

    AC113209, AK097005, AK290730, AK298132, BC006492, CA429204, DA805080, M94165

    Consensus CDS

    CCDS6084.1

    UniProtKB/TrEMBL

    Q7RTW3

    Related

    ENSP00000349275.6, ENST00000356819.7

    Conserved Domains (3) summary

    PHA03099
    Location:182 → 271

    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

    smart00409
    Location:43 → 129

    IG; Immunoglobulin

    cd00054
    Location:190 → 222

    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

19. NM_013958.4 → NP_039252.2  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta3

    See identical proteins and their annotated locations for NP_039252.2

    Status: REVIEWED

    Description

    Transcript Variant: This variant (HRG-beta3), which uses the type I promoter, lacks multiple 3' exons but contains an alternate 3' terminal exon that results in an early stop codon, compared to variant HRG-beta1. The resulting isoform (HRG-beta3, also known as GGF or GGFHFB1) is shorter at the C-terminus, compared to isoform HRG-beta1.

    Source sequence(s)

    AK097005, AK298132, M94165, M94168

    Consensus CDS

    CCDS94274.1

    UniProtKB/TrEMBL

    A0A024QY88, Q6PK61

    Related

    ENSP00000498811.1, ENST00000650919.1

    Conserved Domains (3) summary

    smart00410
    Location:43 → 129

    IG_like; Immunoglobulin like

    pfam00008
    Location:190 → 220

    EGF; EGF-like domain

    cl11960
    Location:53 → 127

    Ig; Immunoglobulin domain

20. NM_013959.4 → NP_039253.1  pro-neuregulin-1, membrane-bound isoform isoform SMDF

    See identical proteins and their annotated locations for NP_039253.1

    Status: REVIEWED

    Description

    Transcript Variant: This variant (SMDF), which uses the type III promoter, is expressed mainly in the nervous system. It lacks multiple 5' and 3' exons but has alternate 5' and 3' terminal exons, and it thus differs in the 5' and 3' coding regions and in both UTRs, compared to variant HRG-beta1. The resulting isoform (SMDF, also known as NRG-III-beta3) has distinct N- and C-termini and is shorter than isoform HRG-beta1.

    Source sequence(s)

    AK289927, M94168

    Consensus CDS

    CCDS6087.1

    UniProtKB/TrEMBL

    Q53F54, Q6ICV5, Q96IB3

    Related

    ENSP00000433289.1, ENST00000520502.7

    Conserved Domains (1) summary

    PHA02887
    Location:236 → 279

    PHA02887; EGF-like protein; Provisional

21. NM_013960.5 → NP_039254.1  pro-neuregulin-1, membrane-bound isoform isoform ndf43 proprotein

    See identical proteins and their annotated locations for NP_039254.1

    Status: REVIEWED

    Description

    Transcript Variant: This variant (ndf43), which uses the type I promoter, lacks two in-frame exons but contains a different in-frame exon in the central coding region, and it also contains an additional exon that results in an alternate 3' coding region, compared to variant HRG-beta1. The resulting isoform (ndf43) has an alternate internal segment and a distinct C-terminus, and is shorter than isoform HRG-beta1.

    Source sequence(s)

    AC113209, AK097005, AK298132, BC006492, CA429204, DA805080, M94165, U02326

    Consensus CDS

    CCDS6086.1

    UniProtKB/TrEMBL

    B0FYA9

    Related

    ENSP00000428828.1, ENST00000521670.5

    Conserved Domains (3) summary

    cd05895
    Location:53 → 127

    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

    pfam00008
    Location:190 → 220

    EGF; EGF-like domain

    pfam02158
    Location:235 → 424

    Neuregulin; Neuregulin family

22. "V体育官网" NM_013962.3 → NP_039256.2  pro-neuregulin-1, membrane-bound isoform isoform GGF2 precursor

    See identical proteins and their annotated locations for NP_039256.2

    Status: REVIEWED

    Description

    Transcript Variant: This variant (GGF2), which uses the type II promoter, is expressed in the nervous system and functions as a neuronal signal that promotes the proliferation and survival of the oligodendrocyte and the myelinating cell. This variant contains alternate 5' and 3' terminal exons and thus differs in the 5' and 3' coding regions and in both UTRs, and it also lacks two alternate in-frame exons in the central coding region, compared to variant HRG-beta1. The resulting isoform (GGF2, also known as GGFHBS5) has distinct N- and C-termini, lacks an internal segment, and is shorter than isoform HRG-beta1.

    Source sequence(s)

    AC104000, L12260, M94165, M94168

    Consensus CDS

    CCDS47836.1

    UniProtKB/Swiss-Prot

    Q02297

    Related

    ENSP00000434640.1, ENST00000520407.5

    Conserved Domains (2) summary

    cd05895
    Location:268 → 342

    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

    cl28647
    Location:362 → 405

    PHA02887; EGF-like protein; Provisional

23. NM_013964.5 → NP_039258.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-alpha proprotein

    See identical proteins and their annotated locations for NP_039258.1

    Status: REVIEWED

    Description

    Transcript Variant: This variant (HRG-alpha), which uses the type I promoter, lacks two in-frame exons but contains a different in-frame exon in the central coding region, compared to variant HRG-beta1. The resulting isoform (HRG-alpha, also known as erbB2 or gp30/alpha 1) contains an alternate internal segment and is shorter than isoform HRG-beta1.

    Source sequence(s)

    AC113209, AK097005, AK298132, BC006492, CA429204, DA805080, M94165

    Consensus CDS

    CCDS6085.1

    UniProtKB/Swiss-Prot

    A5YAK4, A5YAK5, A8K1L2, B7Z4Z3, E9PHH4, O14667, P98202, Q02297, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q15491, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3

    UniProtKB/TrEMBL

    Q7RTV8

    Related

    ENSP00000384620.2, ENST00000405005.8

    Conserved Domains (4) summary

    cd05895
    Location:53 → 127

    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

    smart00410
    Location:43 → 129

    IG_like; Immunoglobulin like

    pfam00008
    Location:190 → 220

    EGF; EGF-like domain

    pfam02158
    Location:235 → 628

    Neuregulin; Neuregulin family