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VSports - CLEC16A C-type lectin domain containing 16A [ Homo sapiens (human) ]

Gene ID: 23274, updated on 9-Sep-2025
Official Symbol
CLEC16Aprovided by HGNC
Official Full Name
C-type lectin domain containing 16Aprovided by HGNC
Primary source
HGNC:HGNC:29013
See related
Ensembl:ENSG00000038532 MIM:611303; AllianceGenome:HGNC:29013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gop-1; KIAA0350
Summary
This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Broad expression in testis (RPKM 11.3), brain (RPKM 3.5) and 24 other tissues See more
Orthologs
mouse all
NEW
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Try the new Transcript table
See CLEC16A in Genome Data Viewer
Location:
16p13.13
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (10944564..11182186)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (10980535..11218466)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11038421..11276043)

Chromosome 16 - NC_000016 VSports最新版本. 10 .

Go to reference sequence details

Genomic Sequence: NC_000016. 10 Chromosome 16 Reference GRCh38. p14 Primary Assembly NG_016757. 1 RefSeqGene NC_060940 V体育平台登录. 1 Chromosome 16 Alternate T2T-CHM13v2. 0 NC_000016. 9 Chromosome 16 Reference GRCh37. p13 Primary Assembly .

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See details
  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

"VSports app下载" Related articles in PubMed

  1. Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus. Mero IL, et al. Genes Immun, 2011 Apr. PMID 21179112
  2. Intron polymorphism in the KIAA0350 gene is reproducibly associated with susceptibility to type 1 diabetes (T1D) in the Han Chinese population. Wu X, et al. Clin Endocrinol (Oxf), 2009 Jul. PMID 19178520
  3. Systemic Lupus Erythematosus Patients Exhibit Reduced Expression of CLEC16A Isoforms in Peripheral Leukocytes. Tam RC, et al. Int J Mol Sci, 2015 Jun 25. PMID 26121298, Free PMC Article
  4. The Role of Autoimmunity-Related Gene CLEC16A in the B Cell Receptor-Mediated HLA Class II Pathway. (V体育官网) Rijvers L, et al. J Immunol, 2020 Aug 15. PMID 32641384
  5. Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis. van Luijn MM, et al. Brain, 2015 Jun. PMID 25823473, Free PMC Article

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CLEC16A-An Emerging Master Regulator of Autoimmunity and Neurodegeneration.
    Title: CLEC16A-An Emerging Master Regulator of Autoimmunity and Neurodegeneration.
  2. CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients.
    Title: CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients.
  3. CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.
    Title: CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.
  4. VSports - An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy.
    Title: VSports - An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy.
  5. Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells.
    Title: Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells.
  6. Mitophagy protects beta cells from inflammatory damage in diabetes.
    Title: Mitophagy protects β cells from inflammatory damage in diabetes.
  7. "VSports注册入口" The Role of Autoimmunity-Related Gene CLEC16A in the B Cell Receptor-Mediated HLA Class II Pathway.
    Title: "VSports注册入口" The Role of Autoimmunity-Related Gene CLEC16A in the B Cell Receptor-Mediated HLA Class II Pathway.
  8. CLEC16A rs12708716 is associated with insulin-triggered type 1 diabetes.
    Title: Variants in the BACH2 and CLEC16A gene might be associated with susceptibility to insulin-triggered type 1 diabetes.
  9. CLEC16A restrains secretory functions including cytokine release and cytotoxicity, and a delicate balance of CLEC16A is needed for NK cell function and homeostasis.
    Title: The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice.
  10. The genotypes of IL-4 (rs2243250)*C/C and CLEC16A (rs6498169)*G/G were associated with primary progressive multiple sclerosis in Russians. The association between the HLA-DRB1*15 and PPMS found out in other populations was confirmed in Russians.
    Title: [Polymorphic variants of the immune response genes as risk factors for primary progressive multiple sclerosis].
Submit: New GeneRIF Correction See all GeneRIFs (50)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Common variants at ten loci influence QT interval duration in the QTGEN Study.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Risk alleles for multiple sclerosis identified by a genomewide study.
EBI GWAS Catalog
EBI GWAS CatalogPubMed
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
EBI GWAS Catalog
EBI GWAS CatalogPubMed

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0350, MGC111457

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
protein CLEC16A
Names
C-type lectin domain family 16 member A

NEW Try the new Transcript table

"V体育官网入口" RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds VSports. Explain.

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build VSports app下载. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above. .

Genomic

  1. NG_016757.1 RefSeqGene

    Range
    5077..242699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243403 V体育官网. 2 → NP_001230332. 1  protein CLEC16A isoform 2.

    See identical proteins and their annotated locations for NP_001230332 VSports手机版. 1 .

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, uses an alternate in-frame splice site and differs in the 3' coding region and UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC112897, BX374760, DB062118, DB069341
    Consensus CDS
    CCDS58423.1
    UniProtKB/Swiss-Prot
    Q2KHT3
    Related
    ENSP00000386495.3, ENST00000409552.4
    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  2. NM_001410905. 1 → NP_001397834. 1  protein CLEC16A isoform 3 V体育安卓版.

    Status: REVIEWED

    Source sequence(s)
    AC007014, AC007220, AC133065
    Consensus CDS
    CCDS92106.1
    UniProtKB/TrEMBL
    A0A8V8TR67
    Related
    ENSP00000515187.1, ENST00000703130.1

  3. NM_015226.3 → NP_056041.1  protein CLEC16A isoform 1

    See identical proteins and their annotated locations for NP_056041.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AB002348, AW072095, DB069341
    Consensus CDS
    CCDS45409.1
    UniProtKB/Swiss-Prot
    O15058, Q2KHT3, Q6ZTB2
    Related
    ENSP00000387122.1, ENST00000409790.6
    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly (V体育2025版)

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    10944564..11182186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255214.3 → XP_005255271.1  protein CLEC16A isoform X5

    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  2. XM_011522434.3 → XP_011520736.1  protein CLEC16A isoform X3

    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  3. XM_005255211.3 → XP_005255268.1  protein CLEC16A isoform X1

    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  4. XM_047433851.1 → XP_047289807.1  protein CLEC16A isoform X8

  5. XM_047433848.1 → XP_047289804.1  protein CLEC16A isoform X6

  6. XM_047433847.1 → XP_047289803.1  protein CLEC16A isoform X4

  7. "VSports最新版本" XM_005255213.3 → XP_005255270.1  protein CLEC16A isoform X2

    Related
    ENSP00000574463.1, ENST00000904404.1
    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  8. XM_047433852.1 → XP_047289808.1  protein CLEC16A isoform X9

    Related
    ENSP00000593470.1, ENST00000923411.1

  9. XM_047433850.1 → XP_047289806.1  protein CLEC16A isoform X7

  10. XM_047433853.1 → XP_047289809.1  protein CLEC16A isoform X10

  11. XM_047433855.1 → XP_047289811.1  protein CLEC16A isoform X14

  12. XM_047433854.1 → XP_047289810.1  protein CLEC16A isoform X11

    Related
    ENSP00000574464.1, ENST00000904405.1

  13. XM_047433856.1 → XP_047289812.1  protein CLEC16A isoform X15

  14. XM_005255215.5 → XP_005255272.1  protein CLEC16A isoform X17

    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  15. XM_005255216.3 (VSports在线直播) → XP_005255273.1  protein CLEC16A isoform X24

    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  16. XM_024450218.2 → XP_024305986.1  protein CLEC16A isoform X18

    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; Uncharacterized conserved protein

  17. XM_047433860.1 → XP_047289816.1  protein CLEC16A isoform X25

  18. XM_047433866.1 → XP_047289822.1  protein CLEC16A isoform X31

  19. VSports最新版本 - XM_011522438.4 → XP_011520740.1  protein CLEC16A isoform X19

    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  20. XM_047433861.1 → XP_047289817.1  protein CLEC16A isoform X26

  21. V体育官网 - XM_047433858.1 → XP_047289814.1  protein CLEC16A isoform X20

  22. VSports最新版本 - XM_047433867.1 → XP_047289823.1  protein CLEC16A isoform X32

  23. XM_047433862.1 → XP_047289818.1  protein CLEC16A isoform X27

  24. V体育2025版 - XM_011522436.4 → XP_011520738.1  protein CLEC16A isoform X12

    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  25. XM_011522437.4 → XP_011520739.1  protein CLEC16A isoform X13

    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  26. "V体育平台登录" XM_011522439.4 → XP_011520741.1  protein CLEC16A isoform X21

    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  27. XM_011522440.4 → XP_011520742.1  protein CLEC16A isoform X22

    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  28. XM_047433863.1 → XP_047289819.1  protein CLEC16A isoform X28

  29. "V体育官网" XM_047433859.1 → XP_047289815.1  protein CLEC16A isoform X23

  30. XM_047433857.1 → XP_047289813.1  protein CLEC16A isoform X16

  31. XM_047433864.1 → XP_047289820.1  protein CLEC16A isoform X29

  32. XM_047433865.1 → XP_047289821.1  protein CLEC16A isoform X30

  33. V体育2025版 - XM_006720870.5 → XP_006720933.1  protein CLEC16A isoform X33

    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  34. XM_047433868.1 → XP_047289824.1  protein CLEC16A isoform X34

  35. XM_017023089.3 → XP_016878578.1  protein CLEC16A isoform X35

  36. "V体育ios版" XM_024450219.2 → XP_024305987.1  protein CLEC16A isoform X36

  37. XM_017023090.3 → XP_016878579.1  protein CLEC16A isoform X37

VSports - Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    10980535..11218466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. V体育官网 - XM_054379921.1 → XP_054235896.1  protein CLEC16A isoform X5

  2. XM_054379919.1 → XP_054235894.1  protein CLEC16A isoform X3

  3. XM_054379917.1 → XP_054235892.1  protein CLEC16A isoform X1

  4. XM_054379924.1 → XP_054235899.1  protein CLEC16A isoform X8

  5. XM_054379922.1 → XP_054235897.1  protein CLEC16A isoform X6

  6. XM_054379920.1 → XP_054235895.1  protein CLEC16A isoform X4

  7. XM_054379918.1 → XP_054235893.1  protein CLEC16A isoform X2

  8. XM_054379925.1 → XP_054235900.1  protein CLEC16A isoform X9

  9. XM_054379923.1 → XP_054235898.1  protein CLEC16A isoform X7

  10. XM_054379926.1 → XP_054235901.1  protein CLEC16A isoform X10

  11. XM_054379930.1 → XP_054235905.1  protein CLEC16A isoform X14

  12. XM_054379927.1 → XP_054235902.1  protein CLEC16A isoform X11

  13. XM_054379931.1 → XP_054235906.1  protein CLEC16A isoform X15

  14. XM_054379933.1 → XP_054235908.1  protein CLEC16A isoform X17

  15. VSports - XM_054379940.1 → XP_054235915.1  protein CLEC16A isoform X24

  16. XM_054379934.1 → XP_054235909.1  protein CLEC16A isoform X18

  17. XM_054379941.1 → XP_054235916.1  protein CLEC16A isoform X25

  18. XM_054379947.1 → XP_054235922.1  protein CLEC16A isoform X31

  19. XM_054379935.1 → XP_054235910.1  protein CLEC16A isoform X19

  20. XM_054379942.1 → XP_054235917.1  protein CLEC16A isoform X26

  21. VSports注册入口 - XM_054379936.1 → XP_054235911.1  protein CLEC16A isoform X20

  22. XM_054379948.1 → XP_054235923.1  protein CLEC16A isoform X32

  23. XM_054379943.1 → XP_054235918.1  protein CLEC16A isoform X27

  24. XM_054379928.1 → XP_054235903.1  protein CLEC16A isoform X12

  25. XM_054379929.1 → XP_054235904.1  protein CLEC16A isoform X13

  26. XM_054379937.1 → XP_054235912.1  protein CLEC16A isoform X21

  27. XM_054379938.1 → XP_054235913.1  protein CLEC16A isoform X22

  28. V体育ios版 - XM_054379944.1 → XP_054235919.1  protein CLEC16A isoform X28

  29. "V体育安卓版" XM_054379939.1 → XP_054235914.1  protein CLEC16A isoform X23

  30. XM_054379932.1 → XP_054235907.1  protein CLEC16A isoform X16

  31. XM_054379945.1 → XP_054235920.1  protein CLEC16A isoform X29

  32. XM_054379946.1 → XP_054235921.1  protein CLEC16A isoform X30

  33. V体育官网入口 - XM_054379949.1 → XP_054235924.1  protein CLEC16A isoform X33

  34. XM_054379950.1 → XP_054235925.1  protein CLEC16A isoform X34

  35. "V体育ios版" XM_054379951.1 → XP_054235926.1  protein CLEC16A isoform X35

  36. XM_054379952.1 (V体育平台登录) → XP_054235927.1  protein CLEC16A isoform X36

  37. "VSports在线直播" XM_054379953.1 → XP_054235928.1  protein CLEC16A isoform X37

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KHT3.2 GenPept UniProtKB/Swiss-Prot:Q2KHT3

Gene LinkOut (VSports注册入口)

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