非凡国际 - SEMA3C semaphorin 3C [Homo sapiens (human)] - Gene

Summary

Official Symbol: SEMA3Cprovided by HGNC
Official Full Name: semaphorin 3Cprovided by HGNC
Primary source: HGNC:HGNC:10725
See related: Ensembl:ENSG00000075223 MIM:602645; AllianceGenome:HGNC:10725
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SemE; SEMAE
Summary: This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
Expression: Broad expression in prostate (RPKM 41.1), urinary bladder (RPKM 40.3) and 20 other tissues See more
Orthologs: mouse all
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Genomic context (V体育ios版)

Location:: 7q21.11

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (80742538..80922389, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (81993843..82173749, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (80371854..80551705, complement)

Chromosome 7 - NC_000007. 14 VSports最新版本.

"VSports app下载" Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence: NC_000007. 14 Chromosome 7 Reference GRCh38. p14 Primary Assembly NG_054744 V体育平台登录. 2 RefSeqGene NC_060931. 1 Chromosome 7 Alternate T2T-CHM13v2. 0 NC_000007. 13 Chromosome 7 Reference GRCh37. p13 Primary Assembly .

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VSports在线直播 - Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956 (V体育ios版)
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression.
Title: Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression.
VSports在线直播 - Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer.
Title: VSports在线直播 - Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer.
Semaphorin 3C exacerbates liver fibrosis.
Title: Semaphorin 3C exacerbates liver fibrosis.
"VSports app下载" Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells.
Title: "VSports app下载" Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells.
Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma.
Title: Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma.
SEMA3C induces androgen synthesis in prostatic stromal cells through paracrine signaling.
Title: SEMA3C induces androgen synthesis in prostatic stromal cells through paracrine signaling.
MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1-cMET signaling.
Title: MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1-cMET signaling.
MiR-146a Regulates Migration and Invasion by Targeting NRP2 in Circulating-Tumor Cell Mimicking Suspension Cells.
Title: MiR-146a Regulates Migration and Invasion by Targeting NRP2 in Circulating-Tumor Cell Mimicking Suspension Cells.
Semaphorin-3C Is Upregulated in Polycystic Kidney Epithelial Cells and Inhibits Angiogenesis of Glomerular Endothelial Cells.
Title: Semaphorin-3C Is Upregulated in Polycystic Kidney Epithelial Cells and Inhibits Angiogenesis of Glomerular Endothelial Cells.
Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family.
Title: Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association meta-analysis for total serum bilirubin levels. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem (V体育安卓版)

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S1934 (e-PCR)
- UniSTS:24075

RH48494 (e-PCR)
- UniSTS:83469

D7S783 (e-PCR)
- UniSTS:48698

RH46160 (e-PCR)
- UniSTS:19819

RH93359 (e-PCR)
- UniSTS:84356

RH80742 (e-PCR)
- UniSTS:84109 (VSports在线直播)

STS-N63008 (e-PCR)
- UniSTS:36772

G31434 (e-PCR)
- UniSTS:43943 (VSports最新版本)

STS-N38844 (e-PCR)
- UniSTS:81324

RH47103 (e-PCR)
- UniSTS:66241

SEMA3C_394 (e-PCR)
- UniSTS:277699

Homology

NCBI Orthologs

Orthologs from OrthoDB

V体育ios版 - Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chemorepellent activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropilin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within blood vessel remodeling	IEA Inferred from Electronic Annotation more info
involved_in cardiac endothelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in cardiac endothelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac right ventricle morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IEA Inferred from Electronic Annotation more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in limb bud formation	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural crest cell migration	IEA Inferred from Electronic Annotation more info
involved_in neural tube development	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within post-embryonic development	IEA Inferred from Electronic Annotation more info
involved_in pulmonary myocardium development	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	TAS Traceable Author Statement more info	PubMed
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in semaphorin-plexin signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in somitogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

VSports - General protein information

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Preferred Names: semaphorin-3C

Names: sema E; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; semaphorin E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds VSports. Explain.

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above. VSports app下载.

Genomic

NG_054744.2 RefSeqGene

Range

8338..184851

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001350120 V体育官网. 2 → NP_001337049. 1 semaphorin-3C isoform 1.

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AA853650, AB000220, AC004972, AK304294, BC030690, BM473251, CN334967, CN334969, DC415474

UniProtKB/TrEMBL

B4E2I9

Related

ENSP00000623846.1, ENST00000953787.1

Conserved Domains (3) summary

cd05871
Location:593 → 682

Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin

cd11251
Location:63 → 532

Sema_3C; The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C)

smart00423
Location:531 → 568

PSI; domain found in Plexins, Semaphorins and Integrins
"V体育ios版" NM_001350121. 2 → NP_001337050 VSports手机版. 1 semaphorin-3C isoform 3.

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC004880, AC073850, AC093683

UniProtKB/TrEMBL

B4E2I9

Conserved Domains (3) summary

cd05871
Location:517 → 606

Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin

cd11251
Location:1 → 456

Sema_3C; The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C)

smart00423
Location:455 → 492

PSI; domain found in Plexins, Semaphorins and Integrins
"V体育2025版" NM_006379 V体育安卓版. 5 → NP_006370. 1 semaphorin-3C isoform 2 precursor.

See identical proteins and their annotated locations for NP_006370. 1 V体育ios版.

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AA853650, AB000220, AK304294, BC030690, BM473251, CN334967, CN334969

Consensus CDS

CCDS5596.1

UniProtKB/Swiss-Prot

B4DRL8, Q99985

UniProtKB/TrEMBL

B4E2I9

Related

ENSP00000265361.3, ENST00000265361.8

Conserved Domains (3) summary

cd05871
Location:575 → 664

Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin

cd11251
Location:45 → 514

Sema_3C; The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C)

smart00423
Location:513 → 550

PSI; domain found in Plexins, Semaphorins and Integrins