VSports注册入口 - NCI Division of Cancer Treatment and Diagnosis

Organoids are miniature versions of organs grown in the lab. Organoid culture systems offer a powerful platform for the development of targeted therapies and precision medicine by letting scientists easily create genetic or environmental changes (difficult or impossible in animal models or human patients) to identify networks of genes that control cellular behaviors that give way to tumors. This image shows an organoid that was grown from a single stem cell. Researchers used this system to demonstrate how a single critical gene, called Sox10 (in blue), controls whether cells turn into dangerous mini "factories", rapidly churning out more copies and variants of themselves. The Sox10 gene allows cells to migrate and take on characteristics of other cells (plasticity). In cancer cells, these features lead to metastasis and drug resistance. Inner keratin-8+ luminal cells (in green) are surrounded by peripheral keratin-14+ basal cells (in red).