VSports手机版 - Targeting Ubiquitin–Proteasome System With Copper Complexes for Cancer Therapy

Citicoline and COVID-19: vis-à-vis conjectured

Al‐kuraishy1, Albuhadily2, Al‐Gareeb3 et al VSports app下载. 2022Naunyn-Schmiedeberg's Arch Pharmacol180460Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Similarly, CTN attenuates tramadol-induced organ injury by inhibiting the generation of ROS and the development of oxidative stress in rats (Abdel-Salam et al 2019 ). CTN significantly reduces expression of MDA with increased expression of antioxidant enzymes and reduced glutathione (GSH) and paraoxonase-1 (PON-1) in rats with experimental cerebral injury (Chen et al 2021 ). Systemic oxidative stress with reduction of PON-1 is linked with severity of preeclampsia and primary hypothyroidism (Al-Kuraishy et al 2018 ; Al-Naimi et al 2018 ). …”Section: Citicoline Oxidative Stress and Hyperinflammationmentioningconfidence: 99%“…The ubiquitin protease system (UPS) is an intracellular proteolytic pathway involved in the regulation of intracellular trafficking, protein synthesis, and folding/degradation of intracellular proteins (Chen et al 2021 ). Dysfunction of UPS is linked with the development of different neurological disorders, including Parkinson disease, Alzheimer’s disease, and amyotropic lateral sclerosis (Gong et al 2016 ). …”Section: Citicoline and Ubiquitin Protease Systemmentioningconfidence: 99%

Citicoline and COVID-19: vis-à-vis conjectured

Al‐kuraishy1, Albuhadily2, Al‐Gareeb3 et al. 2022Naunyn-Schmiedeberg's Arch Pharmacol180460Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Other systems interact with proteosomes and inhibit their function. 26 For instance, a Cu-esclemol complex can interfere in the ferredoxin function and produce cuproptosis, a cell death that occurs independently of apoptosis pathways. 27 …”Section: Introductionmentioningconfidence: 99%“…Other systems interact with proteosomes and inhibit their function. 26 For instance, a Cuesclemol complex can interfere in the ferredoxin function and a Facultad de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000, Circuito Exterior S/N, CU, Ciudad de México, C. P. …”Section: Introductionmentioningconfidence: 99%

Casiopeinas® third generation, with indomethacin: synthesis, characterization, DFT studies, antiproliferative activity, and nanoencapsulation

Godínez-Loyola1, Gracia‐Mora2, Rojas‐Montoya3 et al. 2022RSC Adv. 60130Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In this sense, active research in the field of deubiquitinase signaling have prompted new alternatives. To this matter, copper complexes are found to be able to inhibit different components of the proteasome machinery, and are proposed to be one class of metal-based anticancer drugs with PI activity [ 143 ]. In addition to mediating oxidative damage, combination of Cu(II) to protein samples decreases the thermal stability of ubiquitin [ 144 ], further leading to eventual aggregates of spherical compounds of ubiquitin [ 145 ] which eventually has shown to directly inhibit proteasome activity in different tumor models and cancer cell lines [ 146 ]. …”Section: Introductionmentioningconfidence: 99%

Current approach and novel perspectives in nasopharyngeal carcinoma: the role of targeting proteasome dysregulation as a molecular landmark in nasopharyngeal cancer

Yarza1, Bover2, Agulló-Ortuño3 et al. 2021J Exp Clin Cancer Res260200Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.