"V体育2025版" CCR7 defines a precursor for murine iNKT cells in thymus and periphery

ARTC2.2/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets

Silva1, Wang2, Qian3 et al. 2019The Journal of ImmunologySelf Cite625700Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…T CM also express CD62L and are found primarily in SLO and blood (28). Of note, some staining protocols and tissue processing experiments with these organs involve incubations at room temperature or 37˚C, such as peptide/MHC tetramer enrichment or staining of chemokine receptors (29)(30)(31). We observed that a considerable portion of T CM express high levels of both ARTC2. 2 and P2RX7 (7) (Fig. …”Section: Anti-artc22 Nanobody Blockade Preserves Cd62l Expression Inmentioningconfidence: 61%

"VSports注册入口" ARTC2.2/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets

Silva1, Wang2, Qian3 et al. 2019The Journal of ImmunologySelf Cite625700Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…This transition is accompanied by a strong induction of Plac8 and Ccr7 (Fig. 2d), in line 258 with their migration from the cortex to the medulla (Wang and Hogquist, 2018). Then, iNKT2a 259 appeared as a node that split into two branches leading to either iNKT17, as illustrated by Rorc 260 expression ( Fig. …”mentioningconfidence: 83%“…Comparative analysis between iNKT2a and iNKT2b 181 transcriptomes indicated that iNKT2a were enriched for genes related to tissue emigration such 182 as Klf2 and S100a4 (Weinreich and Hogquist, 2008) (Supplemental Table 3) that may indicate 183 the presence of potential iNKT thymic emigrants as recently proposed (Wang and Hogquist,184 2018). Ccr7 transcripts were also enriched in iNKT2a (Wang and Hogquist, 2018). Table 2). …”mentioningconfidence: 97%

High dimensional single-cell analysis reveals iNKT cell developmental trajectories and effector fate decision

Baranek1, Lebrigand2, Herbozo3 et al VSports app下载. 2020Preprint4100Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…It is thus conceivable that the high expression of Styk1 in thymic NK1. 1 + iNKT cells marks a population of thymus-resident iNKT cells, because previous work showed that only thymic NK1. 1 − iNKT cells emigrate from the thymus to seed the peripheral iNKT cell pools [22,23]. Along this line, a recent study demonstrated that all thymic iNKT effector cells are long-term residents that do not emigrate [24]. In future studies, it will thus be interesting to investigate whether Styk1 expression indicates transcriptional signatures shared by NK cells and thymic Styk1 + NK1. 1 + iNKT cells but not by ILCs and peripheral Styk1 -iNKT cells. …”Section: Styk1 Is Highly Expressed In Thymic But Not In Peripheral αβmentioningconfidence: 99%

Styk1 is specifically expressed in NK1.1⁺ lymphocytes including NK, γδ T, and iNKT cells in mice, but is dispensable for their ontogeny and function

Wilharm1, Sandrock2, Marotel3 et al. 2019Eur J Immunol4110Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.