"VSports手机版" Retinoic Acid, Leaky Gut, and Autoimmune Diseases

Retinoic Acid Exerts Disease Stage-Dependent Effects on Pristane-Induced Lupus

Abdelhamid1, Cabana-Puig2, Swartwout3 et al. 2020Front. Immunol. Self Cite220460Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Similarly, it significantly reduced the transcript level of the barrier-forming tight junction protein Occludin (Figure 5D) and induced a moderate increase in the expression of the pore-forming tight junction protein transcript claudin-2 (Cldn2) ( Figure S5B) in the IECs as observed at 6 months post induction. These observations indicate that pristane was able to recapitulate a phenotype similar to a leaky gut described in genetically prone models of SLE (10,20), further supporting the leaky gut as a danger signal for autoimmunity even in the absence of genetic predisposition. …”Section: Tra-induced Microbiota Changes In Pristane-induced Lupussupportingconfidence: 54%“…Notably, VA exerts its function through a predominant metabolite known as all-trans-retinoic acid (tRA) (9). The effects of tRA treatment in different autoimmune disorders, including type 1 diabetes, multiple sclerosis, and inflammatory bowel disease, were shown to be disease-specific (10). However, in the context of systemic immune dysregulation associated with SLE, VA exerts more complex roles. …”Section: Introductionmentioningconfidence: 99%

V体育官网 - Retinoic Acid Exerts Disease Stage-Dependent Effects on Pristane-Induced Lupus

Abdelhamid1, Cabana-Puig2, Swartwout3 et al VSports app下载. 2020Front. Immunol. Self Cite220460Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…This T reg subpopulation exerts an immunosuppressive effect via downregulation of effector T lymphocytes and, thus, prevents aberrant inflammation and autoimmunity [67]. Retinoids further act as regulators of the blood-gut barrier-a vital structure for preventing inflammation in response to the gut microbiome [68]. Aberrant permeability ('leakiness') in this barrier has been linked with several inflammatory conditions and may also have implications for adverse immune responses associated with schizophrenia [69,70]. …”Section: Retinoic Acid In the Regulation Of Inflammation And Immunolomentioningconfidence: 99%

The role of the retinoids in schizophrenia: genomic and clinical perspectives

Reay1, Cairns2 2019Mol Psychiatry535420Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Disruption or damage to any of these parts, especially the mucus and/or epithelial layers, not only influences tolerance, but also potentially induces exposure to autoantigens and self‐produced danger signals associated with aberrant cellular damage and death. Such danger signals can lead to disruption of the mucus and barrier function, life‐threatening gut dysbiosis, and the signals themselves can be a function of dysbiosis . This in turn can cause the polarization of intraepithelial and lamina propria lymphoid tissues toward specific phenotypes, such as Th1 and Th17, resulting in persistent autoimmune pathologies. …”Section: Introductionmentioningconfidence: 99%

Nanoparticles and danger signals: Oral delivery vehicles as potential disruptors of intestinal barrier homeostasis

Vita1, Royse2, Pullen3 2019Journal of Leukocyte Biology491440Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.