The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

Frizzled-7 Identifies Platinum Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis (VSports在线直播)

Wang1, Zhao2, Condello3 et al. 2020Preprint373362Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The expression of GSR was also higher in TMZ-resistant compared to sensitive cells and silencing GSR in drug-resistant cells improved sensitivity to TMZ or cisplatin (46). Similar results were reported in clear cell renal carcinoma, where silencing the GSH biosynthesis pathway was shown to trigger ferroptosis (47). Thus, modulation of redox homeostasis by GSH/GSR appears to be an important key modulating sensitivity of cancer cells to chemotherapy (46). …”Section: Discussionsupportingconfidence: 63%

Frizzled-7 Identifies Platinum Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis

Wang1, Zhao2, Condello3 et al. 2020Preprint373362Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Compared with two control cell lines, immortalized renal tubule cell line HK-2 and RTCC line BFTC909, all four ccRCC cell lines were more sensitive to GPX4 inhibitors (Figure 1F). These results are consistent with previous characterization of the sensitivity to glutathione depletion or treatment with erastin, a system XC -(SLC7A11) inhibitor and a moderate ferroptosis inducer, within the NCI-60 cancer cell lines [28,29]. shRNA-mediated GPX4 knockdown significantly reduced the viability of 786-O, 769-P and OS-RC2 cells (Figure S1C), suggesting a genetic dependency on GPX4. …”Section: Results Ccrcc Cells Are Intrinsically Susceptible To Gpx4 Insupportingconfidence: 92%“…While the genetic etiology of ccRCC has been illuminated, the lack of actionable targets underscores the pressing need for novel biological insights. Here, our CTRP analyses, along with previous characterizations, link ccRCC to a unique dependency on GPX4 [28,29]. Given GPX4's role in selectively detoxifying lipid hydroperoxides, and that GPX4 inhibition triggers ferroptotic cell death (ferroptosis) [28], we postulate that ccRCC cells are intrinsically susceptible to ferroptosis, and targeting GPX4 represents a therapeutic opportunity in this devastating disease. …”Section: Introductionmentioningconfidence: 52%“…While ferroptotic cell death was first demonstrated in the context of selective sensitivity in fibroblasts engineered with forced expression of an oncogenic allele of HRAS [47, 92], our work underscores a prominent example of "oncogenesis-associated ferroptosis susceptibility" in human cancers. The involvement of HIF-2a in ferroptosis was indirectly supported by a recent report showing that pVHL restoration reverted the sensitivity to erastin and L-buthionine-S,R-sulfoximine (BSO) in RCC4 cells, although the mechanisms mediating pVHL's action was not elucidated [29], and nonferroptotic contributions to death by these two agents are suggested by the partial rescue using ferrostatin-1. Here we report that HIF-2a selectively enriches PUFAs rather than SFA/MUFAs, up-regulates the abundances of PUFA-TAGs as well as PUFA-phospholipids, and induces a GPX4-dependent, ferroptosis-susceptible state in ccRCC cells. …”Section: Discussionmentioningconfidence: 94%See 1 more Smart Citation

HIF-2α drives an intrinsic vulnerability to ferroptosis in clear cell renal cell carcinoma

Zou1, Palte2, Deik3 et al. 2018Preprint240260Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC) VSports app下载. Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Slc7a11 encodes a component of system x c - (cystine/glutamine transporter) (Sato et al, 2005, Sato et al, 2000) and a well-known regulator of ferroptosis (Jiang et al, 2015). Gclm and Gclc encode glutamate-cysteine ligase modifier and catalytic subunits (Fan et al, 2012, Telorack et al, 2016), both considered to suppress ferroptosis by GSH synthesis (Miess et al, 2018, Stockwell et al, 2017). These genes for the pathway of GSH synthesis are also considered to be targets of BACH1 (Warnatz et al, 2011). …”Section: Resultsmentioningconfidence: 99%

"V体育官网入口" Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1

Nishizawa1, Matsumoto2, Shindo3 et al. 2019Preprint5070Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.