Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome

The N-end rule E3 ligase UBR2 activates Nlrp1b inflammasomes

Xu1, Shi2, Yang3 et al. 2018Preprint3120Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Recent studies have established that DPP8/9 inhibitors can activate Nlrp1b inflammasomes and have shown proteasome inhibitors can block this activation 38,39 . …”Section: Discussionmentioningconfidence: 99%

"VSports在线直播" The N-end rule E3 ligase UBR2 activates Nlrp1b inflammasomes

Xu1, Shi2, Yang3 et al. 2018Preprint3120Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD VSports app下载. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In the process of activation, the FIIND undergoes self‐cleavage, an event that is required for activation. NLRP1 responds to the enzymatic activities of pathogen effectors such as the lethal toxin (leTox) from Bacillus anthracis and by non‐pathogen‐associated triggers such as the drug Val‐boro‐Pro, an anti‐cancer molecule that inhibits the cytosolic serine proteases Dpp8 and Dpp9 …”Section: Nlrs Function As Sensors Of Pathogens and Cellular Perturbatmentioningconfidence: 99%“…NLRP1 responds to the enzymatic activities of pathogen effectors such as the lethal toxin (leTox) from Bacillus anthracis 21 and by non-pathogen-associated triggers such as the drug Val-boro-Pro, an anti-cancer molecule that inhibits the cytosolic serine proteases Dpp8 and Dpp9. 22,23 Gain-of-function mutations within NLRP1 have been described in humans to cause uncontrolled inflammasome activation promoting a familial autoinflammatory skin disease associated with cancer. 24 Other mutations of NLRP1 have been linked to autoinflammation with arthritis and dyskeratosis (AIADK) also known as NAIAD (NLRP1-associated autoinflammation with arthritis and dyskeratosis). …”Section: Nlr S Fun C Ti On a S S En Sor S Of Pathog En S And Cellulmentioningconfidence: 99%

Inflammasomes contributing to inflammation in arthritis

Spel1, Martinon2 2020Immunological Reviews16511060Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…60 PAPA syndrome is caused by heterozygous mutations in PSTPIP1 and although it is understood that the inflammatory manifestations in PAPA syndrome are pyrin dependent, 61,62 the exact mechanism of disease is unclear. [66][67][68][69] An autosomal recessive form of generalised pustular psoriasis has also been described. 63 Two rare dermatological conditions, multiple selfhealing palmoplantar carcinoma and familial keratosis lichenoides chronica, have recently been linked to activating heterozygous mutations in NLRP1. …”Section: Dermatological Presentationmentioningconfidence: 99%“…Recently, a specific endogenous inhibitor of NLRP1, DPP9, has been identified and it will be interesting to see whether treatment options based on this protein are developed. [66][67][68][69] An autosomal recessive form of generalised pustular psoriasis has also been described. Homozygous missense mutations in IL36RN, causing deficiency in IL-36 receptor antagonist (IL-36Ra, DITRA), lead to unregulated signalling through the IL-36 receptor. …”Section: Dermatological Presentationmentioningconfidence: 99%

Monogenic autoinflammatory disorders: beyond the periodic fever

Moghaddas1 2020Internal Medicine Journal12070Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.