Ontogeny of human mucosal-associated invariant T cells and related T cell subsets

V体育ios版 - Development of mucosal‐associated invariant T cells

Koay1, Godfrey2, Pellicci3 2018Immunol Cell Biol516500Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…A similar correlation between MAIT cells and NKT cell frequencies was shown in neonates in a recent study by Ben Youssef and colleagues . Moreover, they also demonstrated a parallel relationship between Vα7. 2 + and Vα7. 2 − subsets of CD161 + T cells and while the latter population did not bind MR1 tetramer, their data suggests that both populations undergo a similar postnatal development pathway …”Section: Homeostasis and Expansion Of Mait Cellssupportingconfidence: 79%“…Notably, the vast majority of human thymic MAIT cells lack expression of CD161 and these cells would have been excluded from previous studies that relied on CD161 as a surrogate marker of MAIT cells . In addition, we also found many MAIT‐like Vα7. 2 + CD161 + T cells in human thymus that do not bind MR1‐5‐OP‐RU tetramer, a result that was recently observed by another group with human cord blood and neonatal blood samples . The majority of peripheral blood MAIT cells have upregulated CD161 and IL‐18R, although residual CD161 − IL‐18R − MAIT cells could still be found in cord blood and young peripheral blood . …”Section: A Three‐stage Pathway For Mait Cell Development In Mice and supportingconfidence: 56%“…The discovery of riboflavin derivatives as antigens (Ags) for MAIT cells (described in this issue by Kjer‐Nielsen, Corbett and colleagues), coupled with the production of MR1 tetramers that incorporate these Ags, has fueled new studies into the development and function of MAIT cells. These tetramer reagents now provide a basis for distinguishing MAIT cells from other T‐cell populations that share similar phenotypic markers …”Section: Introductionmentioningconfidence: 99%See 1 more Smart Citation

Development of mucosal‐associated invariant T cells

Koay1, Godfrey2, Pellicci3 2018Immunol Cell Biol516500Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…A thorough ontogenetic study of human MAIT found a similar scenario to the dNKT and Vδ1+ T cells; TCRβ diversity is high in cord blood, with the Vα7. 2+ population phenotypically naïve, but during childhood a few dominate clones are selected by antigenic stimulation, acquire effector memory, and stabilize (60). MAIT cells account for ~1–10% of all αβ T cells in peripheral blood making for a large pool of innate-like lymphocytes focused at one, conserved molecular pattern (mouse MAITs are considerably lower in frequency). …”Section: The Unconventional αβ T Cellsmentioningconfidence: 97%

"VSports手机版" Bohemian T cell receptors: sketching the repertoires of unconventional lymphocytes

Schattgen1, Thomas2 2018Immunological Reviews10030Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD VSports app下载. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…These T cells display a naïve phenotype (CD45RA + RO − ), a diverse (naïve) repertoire and most of them do not express TRAV1 . Moreover, only a small proportion of TRAV1 + CD161 hi T cells are labeled with 5‐OP‐RU:MR1 tetramers . After birth, only the T cells recognizing 5‐OP/E‐RU:MR1 complexes become memory and expand to high clonal size diluting out the other T cells . …”Section: Heterogeneity Of Mait Cells And/or Heterogeneity Of Mait Ligmentioningconfidence: 99%

"V体育平台登录" MAIT cells: an historical and evolutionary perspective

Lantz1, Legoux2 2017Immunol Cell BiolSelf Cite380300Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.