Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile

VSports app下载. However, it is unknown if these changes in stability are responsible for driving changes in SPI-1 expression in bile, or rather reflects an indirect effect on HilD stability, for example, via alteration of DNA binding (as DNA-bound HilD is proposed to be more stable; Grenz, Cott Chubiz, Thaprawat, & Slauch, 2018). …”Section: Regulation Of the T3sssmentioningconfidence: 99%“…Although S. Typhimurium is a commonly used and long-held model, several studies have observed marked phenotypic differences between S. Typhimurium and typhoidal serovars (Bishop et al, 2008;Elhadad et al, 2016;Elhadad, McClelland, Rahav, & Gal-Mor, 2015;Eswarappa et al, 2008;Johnson et al, 2017Johnson et al, , 2018, in addition to describing important roles for typhoidal-specific virulence factors (Haghjoo & Galán, 2004;Song, Gao, & Galán, 2013;Wilson et al, 2008Wilson et al, , 2011Winter et al, 2015;Yang et al, 2018). This review will therefore discuss what is known about virulence and pathogenesis of S. Typhi and emphasise differences between typhoidal and NTS. …”mentioningconfidence: 99%See 2 more Smart Citations

TyphoidalSalmonella: Distinctive virulence factors and pathogenesis

Johnson1, Mylona2, Frankel3 2018Cellular MicrobiologySelf Cite17331430Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The mechanism(s) underpinning this difference are at present poorly characterized, but the stability of the dominant SPI-1 regulator HilD is increased approximately threefold in S. Typhi in bile, but decreased over threefold in S. Typhimurium in bile (Eade et al, 2016;Johnson et al, 2018). The mechanism(s) underpinning this difference are at present poorly characterized, but the stability of the dominant SPI-1 regulator HilD is increased approximately threefold in S. Typhi in bile, but decreased over threefold in S. Typhimurium in bile (Eade et al, 2016;Johnson et al, 2018). …”Section: Regulation Of the T3sssmentioningconfidence: 99%“…Typhi, growth in bile results in significant upregulation of the SPI-1 T3SS and its associated genes, resulting in a significant increase in epithelial cell invasion . The mechanism(s) underpinning this difference are at present poorly characterized, but the stability of the dominant SPI-1 regulator HilD is increased approximately threefold in S. Typhi in bile, but decreased over threefold in S. Typhimurium in bile (Eade et al, 2016;Johnson et al, 2018). However, it is unknown if these changes in stability are responsible for driving changes in SPI-1 expression in bile, or rather reflects an indirect effect on HilD stability, for example, via alteration of DNA binding (as DNA-bound HilD is proposed to be more stable; Grenz, Cott Chubiz, Thaprawat, & Slauch, 2018). …”Section: Regulation Of the T3sssmentioningconfidence: 99%“…Although S. Typhimurium is a commonly used and long-held model, several studies have observed marked phenotypic differences between S. Typhimurium and typhoidal serovars (Bishop et al, 2008;Elhadad et al, 2016;Elhadad, McClelland, Rahav, & Gal-Mor, 2015;Eswarappa et al, 2008;Johnson et al, 2017Johnson et al, , 2018, in addition to describing important roles for typhoidal-specific virulence factors (Haghjoo & Galán, 2004;Song, Gao, & Galán, 2013;Wilson et al, 2008Wilson et al, , 2011Winter et al, 2015;Yang et al, 2018). This review will therefore discuss what is known about virulence and pathogenesis of S. Typhi and emphasise differences between typhoidal and NTS. …”mentioningconfidence: 99%See 1 more Smart Citation

TyphoidalSalmonella: Distinctive virulence factors and pathogenesis

Johnson1, Mylona2, Frankel3 2018Cellular MicrobiologySelf Cite17331430Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The conditions and location of these recalcitrant infections is both perplexing and problematic. Bile is rich in bile acids and bile salts with extensive immune-stimulating, antimicrobial, and detergent-like properties that can disrupt bacterial membranes, halt proton gradients, and induce redox stress [6,7]. How and why S. Typhi establishes chronic infections in such a repressive environment is not well understood [7]. …”Section: Introductionmentioningconfidence: 99%

Salmonella Extracellular Polymeric Substances Modulate Innate Phagocyte Activity and Enhance Tolerance of Biofilm-Associated Bacteria to Oxidative Stress

Hahn1, Gunn2 2020Microorganisms321381Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Cases of the disease among African children decrease, and increase in the acquisition of the antibody to start all complement-dependent killing of Salmonella, and subsequently, more effective blood phagocytes and opsoniza-tion (4)(5)(6). Measuring and detecting serum antibody markers in the clinical laboratory to evaluate a patient's health status is an important and valuable issue (6)(7)(8)(9)(10)(11). …”Section: Introductionmentioningconfidence: 99%

Quantitative Assessment of an Artificial Neural Network for the Variation in Immunity to Salmonella Infection Among Sudanese and Chinese Populations and the Relationship Between HLA-DQB1 and Antibody: A Preliminary Study

Tamomh1, Liu2 2020Jundishapur J Microbiol0000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.