Mechanism of the Ullmann Biaryl Ether Synthesis Catalyzed by Complexes of Anionic Ligands: Evidence for the Reaction of Iodoarenes with Ligated Anionic Cu^I Intermediates

Scope, Kinetics, and Mechanism of “On Water” Cu Catalysis in the C–N Cross‐Coupling Reactions of Indole Derivatives

Malavade1, Patil2, Patil3 2020Eur J Org Chem17070Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…A comparison of energetics of different pathways suggests that oxidative addition of iodobenzene to Cu complex is a rate‐limiting step for this reaction. This finding is concurrent with the other related reports on the C–heteroatom cross‐coupling reactions , , , . Out of four pathways discussed for the oxidative addition step, the pathway involving SET from Cu complex to aryl iodide ( OA‐III ) is prohibited because of very high barrier required for electron transfer process. …”Section: Computational Studiessupportingconfidence: 92%“…Hence, in our experiments, we rely on isolated product and un‐reacted reactant in order to determine meaningful kinetic parameters . The kinetics of copper catalyzed Ullmann type reactions have been extensively investigated and used to elucidate mechanism of reactions . In this study, we used four different solvent systems (H 2 O, 30 % DME/H 2 O, 15 % DME/H 2 O and DME) to assess the rate enhancement in DME/H 2 O as compared to DME. …”Section: Kinetic Analysismentioningconfidence: 99%

"VSports在线直播" Scope, Kinetics, and Mechanism of “On Water” Cu Catalysis in the C–N Cross‐Coupling Reactions of Indole Derivatives

Malavade1, Patil2, Patil3 2020Eur J Org Chem17070Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC) VSports app下载. Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Cu(OTf) was found to give the highest yield, while no desired product was observed with Cu(OTf) 2 (entries 7-12). Significantly reduced yields of 3a (< 3%)w ere observed in the absence of these components (entries [18][19][20]. Interestingly,t he ratio and amounts of Cu(OTf) and CsF significantly influenced the reaction yield, and the highest yield was obtained when 1. 0 equiv of Cu(OTf) and 2equiv of CsF were used (entries 7, 8). …”mentioningconfidence: 99%“…When 4. 0 equiv of TEMPO was added, no trifluoromethoxylated product was obtained, and the TEMPO-trapped intermediate (13)w as isolated in 74 %y ield. [19] In addition, the highest yield of product 3a was CuOTfC sF 78 8 [b] [Ru (bpy) CuOTfn one 0 16 [c] [Ru(bpy) 3 ](PF 6 ) 2 CuOTfC sF 61 17 [d] [Ru ( was the reactive species for this reaction (Scheme 2b). To verify the effect of photoirradiation, the value of F was estimated to be 0. 38, which indicates that aradical-chain process is unlikely in the reaction. …”mentioningconfidence: 99%“…[b] Yields were determined by 19 FNMR with benzotrifluoride as astandard. This new method takes advantage of visiblelight photoredox catalysis to generate the aryl radical under mild conditions,c ombined with copper-promoted selective trifluoromethoxylation. …”mentioningconfidence: 99%See 1 more Smart Citation

Visible‐Light Photoredox‐Catalyzed and Copper‐Promoted Trifluoromethoxylation of Arenediazonium Tetrafluoroborates

Yang1, Chen2, Tang3 2019Angew Chem Int Ed650330Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

Theoretical Study of Cu‐Catalysis

2021Computational Methods in Organometallic Catalysis0000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Scite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.