Safety in treatment of hepatocellular carcinoma with immune checkpoint inhibitors as compared to melanoma and non-small cell lung cancer

Liver Toxicity with Cancer Checkpoint Inhibitor Therapy

Nadeau1, Fecher2, Owens3 et al. 2018Semin Liver Dis311200Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD VSports app下载. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…A literature review comparing TRAEs with singleagent immune checkpoint inhibitor therapy (ipilimumab, nivolumab, pembrolizumab, or tremelimumab) in HCC, NSCLC, and melanoma demonstrated that patients with HCC had a statistically significant increase in transaminases of any grade compared with the other groups, as anticipated since most of these patients have underlying liver disease at treatment onset. 57 Among patients treated for HCC, the incidence of any grade increase in AST or ALT was approximately 16 and 13%, respectively; the rate of grade 3/4 elevation of AST was 9. 6% and of ALTwas 5%. This contrasts with NSCLC in which any grade increase in AST or ALT occurred in only 2. 3 and 2. 5% of patients, respectively. …”Section: Relationship Of Tumor Type and Hepatic Iraesmentioningconfidence: 92%

Liver Toxicity with Cancer Checkpoint Inhibitor Therapy

Nadeau1, Fecher2, Owens3 et al. 2018Semin Liver Dis311200Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…There was concern on possible immune mediated liver toxicity in patients with liver cirrhosis and chronic HBV or HCV infection. However, until now safety profile of ICIs has not shown to be different from what observed for melanoma and non-small cell lung cancer (NSCLC) and even if substantial transaminase flares have been described, patients coming off therapy for adverse events are in line with what observed for other cancers treated with anti-PD-1 or anti-PD-L1 [136] . …”Section: Immune Checkpoint Inhibitorsmentioningconfidence: 85%

Time for hepatocellular carcinoma immunotherapy: insights for successful clinical applications in this challenging tumor

Missale1, Cariani2 2018HR3010Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…At present, Sorafenib (a multitargeted small molecule tyrosine kinase inhibitor (TKI)) is the unique first-line therapy drug of advanced HCC which is approved by the Food and Drug Administration (FDA) [23][24][25][26]. In the second-line therapy, Nivolumab (a PD-1 antibody) and Regorafenib (a vascular endothelial growth factor receptor (VEGFR) inhibitor) have been preliminary used, respectively or combined, especially in patients who have been previously treated with Sorafenib [27,28]. Besides, another VEGFR/fibroblast growth factor receptor (FGFR)/PDGFR inhibitor Lenvatinib, which has not merely been approved by FDA, is a reasonable first-line alternative to Sorafenib, especially for patients who cannot tolerate Sorafenib [29,30]. …”Section: Discussionmentioningconfidence: 99%

An Epitope on EGFR Loading Catastrophic Internalization Serve as a Novel Oncotarget for Hepatocellular Carcinoma Therapy (V体育官网)

Huang1, Fan2, Liu3 et al. 2020Cancers1030Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.