The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy

VSports app下载. …”Section: Cd27mentioningconfidence: 99%

Selecting costimulatory domains for chimeric antigen receptors: functional and clinical considerations

Weinkove1, George2, Dasyam3 et al. 2019Clin & Trans Imm28542590Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…46 Unlike the other TNFR family members, CD27 is present at the cell surface as a disulphide-linked homodimer and its expression is upregulated upon T cell activation. 46 Unlike the other TNFR family members, CD27 is present at the cell surface as a disulphide-linked homodimer and its expression is upregulated upon T cell activation. …”Section: Cd27mentioningconfidence: 99%

Selecting costimulatory domains for chimeric antigen receptors: functional and clinical considerations (V体育安卓版)

Weinkove1, George2, Dasyam3 et al. 2019Clin & Trans Imm28542590Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…OX40 is expressed constitutively by a subset of Treg cells, but also on activated non‐Treg cells . In cancer, Treg cells can comprise a significant proportion of tumour‐resident OX40 + cell types . …”Section: Regulation Of Treg Cells In Cancermentioningconfidence: 99%“…Administration of agonistic reagents demonstrates that OX40‐signalling reduces Treg cell suppressive function in vitro and in vivo ; however, other studies suggest that Treg cells are not impaired . One potential explanation is that the context of OX40 ligand (OX40L) expression can have different effects on Treg cells . In the context of cancer, OX40L is expressed by glioblastoma, especially under hypoxic conditions. …”Section: Regulation Of Treg Cells In Cancermentioningconfidence: 99%“…CD27 is expressed mainly by naive and subsets of memory CD4 + and CD8 + T cells, as well as Treg cells . CD70 can be expressed by antigen‐presenting cells, but also by tumour‐infiltrating Treg and effector T cells . …”Section: Regulation Of Treg Cells In Cancermentioningconfidence: 99%“…112 OX40 is expressed constitutively by a subset of Treg cells, but also on activated non-Treg cells. 113 In cancer, Treg cells can comprise a significant proportion of tumour-resident OX40 + cell types. [114][115][116] Although OX40agonistic reagents are used to stimulate anti-tumour Tcell responses, the effect on Treg cells in cancer is not well understood. …”Section: Co-stimulatory Receptorsmentioningconfidence: 99%See 2 more Smart Citations

VSports在线直播 - Regulation of regulatory T cells in cancer

Stockis1, Roychoudhuri2, Halim3 2019Immunology621381Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

V体育平台登录 - Lymphocyte development and function

Lim1 2025Hoffbrand's Postgraduate Haematology0000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Scite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.