Eomesodermin promotes the development of type 1 regulatory T (T _R 1) cells

Eomesodermin driven IL-10 production in effector CD8+ T cells promotes a memory phenotype

Reiser1, Sadashivaiah2, Furusawa3 et al. 2019Cellular Immunology161130Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Here, we identified IL-10 as an early target of Eomes in activated CD8 + T cells, and show that Eomes and IL-10 act independently to regulate CD62L expression. Our data are in line with a recent study demonstrating that Eomes directly binds the IL-10 promoter in CD4 + Tr1 cells and induces IL-10 expression (42). Similarly, CCR6 + Th17 cells express high levels of both Eomes and IL-10 in experimental autoimmune encephalitis (48). …”Section: Discussionsupportingconfidence: 93%“…al. found that Eomes directly bound to and promoted IL-10 expression in CD4 + Tr1 cells (42). However, a connection with Eomes as a regulator of IL-10 in CD8 + T cells has not been studied. …”Section: Resultsmentioningconfidence: 99%

Eomesodermin driven IL-10 production in effector CD8+ T cells promotes a memory phenotype

Reiser1, Sadashivaiah2, Furusawa3 et al. 2019Cellular Immunology161130Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Bacchetta et al (2014) (Table 3). CXCL11, CXCL12, and AhR-c-Maf are used to treat MS (Table 1) that it has great therapeutic potential, but because it is highly dynamic in vivo, there are still few studies available (Gruarin et al, 2019;Zhang et al, 2017). Although there are still many unknowns in Tr1 cell-related therapy, it is a research hotspot in the field of clinical immunology currently, and its public recognition will be definitely deepened in the near future. …”Section: The Therapeutic Prospect Of Engineered Tr1mentioningconfidence: 99%

Decreased number and impaired function of type 1 regulatory T cells in autoimmune diseases

Jia1, Zhai2, Wang3 et al. 2019Journal Cellular Physiology201140Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Although alloSCT is an established curative therapy for a range of haematological malignancies, a major limitation is acute GVHD, where alloreactive naive donor T cells differentiate into pro-inflammatory effectors that damage the GI tract, liver and skin (1). Cytokines such as IL-17A, IFNγ and GM-CSF produced by allo-reactive Th1 and Th17 cells in the GI tract promote disease (21), while IL-10 produced by Tr1 and iTreg cells can protect (22). An important goal in alloSCT is to preserve GVL effects while reducing GVHD. …”Section: Discussionmentioningconfidence: 99%

Single-cell transcriptomics of allo-reactive CD4^{VSports在线直播 - +}T cells over time reveals divergent fates during gut GVHD

Engel1, Lee2, Williams3 et al. 2020PreprintSelf Cite0000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility VSports app下载. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.