FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation

Molecular Effects of FDA-Approved Multiple Sclerosis Drugs on Glial Cells and Neurons of the Central Nervous System

Kleijn1, Martens2 2020IJMS320311Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…FTY720 reduced the number of cells positive for reactive A1 astrocytic markers glial fibrillary acidic protein (GFAP) and S100 calcium-binding protein B (S100β) in multiple rodent models, including in a model of familial AD [45,51], cuprizone-induced demyelination [48], MS [50,61,82], Huntington's disease (HD) [84], Status epilepticus (SE) [54], and models of infection [85], stroke [86], ICH [47], Pentylenetetrazol (PTZ)-induced kindling [56], and maternal inflammation [87] as well as wild-type rodents [88]. In contrast, FTY720-treated immortalized astrocytes displayed increased release of the astrocyte-secreted protein GM-CSF [89], whereas LPS-stimulated primary astrocytes decreased GM-CSF release following treatment with FTY720 [65]. …”Section: Astrocytesmentioningconfidence: 99%

Molecular Effects of FDA-Approved Multiple Sclerosis Drugs on Glial Cells and Neurons of the Central Nervous System

Kleijn1, Martens2 2020IJMS320311Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In the same time, fingolimod reduced Aβ 42 plaque density and the total level of Aβ 42 [77]. The mechanism of Aβ accumulation may be augmented by proinflammatory environment in the diseased brain, which is suggested to impair Aβ clearance by astrocytes [78]. Mice overexpressing AβPP and presenilin 1 display activated local astroglia and microglia, infiltration of peripheral macrophages and natural killer cells [79]. …”Section: Discussionmentioningconfidence: 99%“…Mice overexpressing AβPP and presenilin 1 display activated local astroglia and microglia, infiltration of peripheral macrophages and natural killer cells [79]. Infections, susceptibility to which rises in old age, are noted to accelerate the cognitive deterioration of AD patients [80] and to increase Aβ burden in animal models [78]. FTY720 has been shown to inhibit the infection-related activation of astrocytes, and to prevent accumulation of soluble and plaque Aβ in the mouse brain probably through stimulation of Aβ phagocytosis [78]. …”Section: Discussionmentioningconfidence: 99%“…Infections, susceptibility to which rises in old age, are noted to accelerate the cognitive deterioration of AD patients [80] and to increase Aβ burden in animal models [78]. FTY720 has been shown to inhibit the infection-related activation of astrocytes, and to prevent accumulation of soluble and plaque Aβ in the mouse brain probably through stimulation of Aβ phagocytosis [78]. Fingolimod also restores neurotrophin production and blocks neuronal death occurring in response to Aβ [34,81]. …”Section: Discussionmentioningconfidence: 99%See 1 more Smart Citation

Fingolimod Affects Transcription of Genes Encoding Enzymes of Ceramide Metabolism in Animal Model of Alzheimer’s Disease

Jęśko1, Wencel2, Wójtowicz3 et al. 2020Mol Neurobiol270270Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Both fingolimod species can be released into the extracellular space and bind either as agonist or as modulator to 7-TM spanning G-protein coupled sphingosine-1-phosphate receptors (S1PR 1-5 ; compare (Angelopoulou and Piperi, 2019)). Fingolimod induced activation of microglial S1PRs was shown to interfere with microglia activation in the cortex of 5xFAD mice (Aytan et al, 2016), to inhibit neuronal Aβ production (Takasugi et al, 2013), to decrease Aβ 42 and Aβ 40 levels in the brain of AD mouse models (Aytan et al, 2016;McManus et al, 2017), to regulate Aβ traffic across the BBB (Sanabria-Castro et al, 2017), and to promote the conversion of pro-inflammatory M1 microglia to the anti-inflammatory M2 state (Qin et al, 2017). With respect to astroglia, fingolimod treatment was shown recently to reduce astrocyte activation and to increase Aβ phagocytosis by astrocytes (McManus et al, 2017). …”Section: The Role Of Neuro-inflammation In Fingolimod-dependent Rescumentioningconfidence: 99%

Anti-inflammatory treatment with FTY720 starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model

Kartalou1, Pereira2, Endres3 et al. 2019Preprint1000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.