Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets

Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites

Thinon1, Fernandez2, Molina3 et al. 2018J. Proteome Res. 706840Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…1–3 The main types of protein fatty-acylation are S-fatty-acylation, N-myristoylation, O-fatty acylation and NεLys-fatty-acylation. They differ in the fatty acid chain length and the modified amino acid. …”Section: Introductionmentioningconfidence: 99%“…3,5 Several methods have been developed to visualize and capture S-fatty-acylated proteins (Figure 1). One approach employs alkyne-tagged palmitic acid chemical reporter, alk-16, for metabolic labeling followed by bioorthogonal tagging of cell lysates with azide-fluorophores for detection or affinity tags for enrichment (Figure 1A). …”Section: Introductionmentioningconfidence: 99%

Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites

Thinon1, Fernandez2, Molina3 et al. 2018J. Proteome Res. 706840Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC) VSports. Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Among these, lipid modifications have been shown to affect various features of proteins, including activity, localization, protein stability and their interaction with other proteins [1,2]. Moreover, S-acylation is distinguished from other lipid modifications by its reversibility, which renders it especially suitable for the regulation of fast biological processes like signal transduction events [3]. In contrast, myristoylation usually modifies the N terminus of proteins that harbor a MGXXXS/T consensus motif [1,2]. …”mentioningconfidence: 99%

"VSports最新版本" N‐terminal S‐acylation facilitates tonoplast targeting of the calcium sensor CBL6

Zhang1, Beckmann2, Kudla3 et al. 2017FEBS Letters224160Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Notably, palmitoylation is a reversible modification, that is, proteins can cycle between palmitoylated and depalmitoylated forms on timescales that range from seconds to hours (Rocks et al, ). Dynamic palmitoylation can impact protein localization, accumulation, secretion, stability, and function by altering membrane affinity and has been suggested to be critically involved in the regulation of multiple signaling processes by modulating protein localization and trafficking among the plasma membrane, the intracellular membrane and the cytoplasm as well as modulating the coupling of specific signaling proteins to their effectors (Jiang et al, ; Kanaani, Patterson, Schaufele, Lippincott‐Schwartz, & Baekkeskov, ; Lanyon‐Hogg, Faronato, Serwa, & Tate, ; Martin, Wang, Adibekian, Tully, & Cravatt, ; Percherancier et al, ; Rocks et al, ). Moreover, palmitoylation may also regulate protein activity in diverse ways, such as inducing protein conformational changes, modulating protein stability and protein–protein interactions and interacting with other posttranslational modifications (Abrami et al, ; Tian et al, ; Valdez‐Taubas & Pelham, ). …”Section: Introductionmentioningconfidence: 99%

Functional importance of palmitoyl protein thioesterase 1 (PPT1) expression by Sertoli cells in mediating cholesterol metabolism and maintenance of sperm quality

Zhao1, Su2, Wang3 et al. 2019Molecular Reproduction Devel7020Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.