VSports app下载 - GATA factors: Master regulators of gene expression in trophoblast progenitors

Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

Everson1, Vives-Usano2, Seyve3 et al. 2019Preprint8130Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Our CpGs were also enriched for genes regulated by specific transcription factors, most notably GATA1 and GATA2. Together with PPARG and TP63, GATA factors are part of the core transcriptional regulatory circuit that guides and maintains proper trophoblast differentiation 45,46 . Placentas lacking PPARG have lethal defects in placental vascularisation 43 , and angiogenic activity is reduced in placentas lacking GATA2 47 . …”Section: Discussionmentioningconfidence: 99%

Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

Everson1, Vives-Usano2, Seyve3 et al. 2019Preprint8130Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In hematopoiesis, GATA3 is involved in the earliest steps of Tcell development in the thymus, 23 and is expressed exclusively in quiescent long-term hematopoietic stem cells that are responsible for long-term, lineagespecific repopulation. 27 In fibroblasts, OCT4 can be replaced by GATA3 to reprogram both human and mouse fibroblasts to induced pluripotent stem cells (iPSCs). 25 In neural progenitor cells, GATA3 is induced after injury, and is required for regenerative neurogenesis, 26 and ensures self-renewal in both human and mouse trophoblastic stem cells. …”Section: Discussionmentioningconfidence: 99%“…25 In neural progenitor cells, GATA3 is induced after injury, and is required for regenerative neurogenesis, 26 and ensures self-renewal in both human and mouse trophoblastic stem cells. 27 In fibroblasts, OCT4 can be replaced by GATA3 to reprogram both human and mouse fibroblasts to induced pluripotent stem cells (iPSCs). 28,29 Together, all these studies suggest a stemness role for GATA3 in developmental biology. …”Section: Discussionmentioningconfidence: 99%

GATA3 as a master regulator and therapeutic target in ovarian high‐grade serous carcinoma stem cells

Chen1, Huang2, Liew3 et al. 2018Intl Journal of Cancer351260Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Thus, the precise mechanism of the effect of T3 on the GATA2-related hematopoiesis should be investigated in future. Current results also predict that serum TSH level may be correlated with placental function because this organ expresses GATA family members [32,33] as well as TRs [86]. As is the case with the TSHβ and CGA gene in the pituitary (Fig 7), GATA2 and GATA3 regulate the expression of the genes that encode the critical proteins responsible for maintaining the placental function, including the component of bone morphogenetic protein 4, Nodal and Wnt signals [32]. …”Section: Fig 7 a Schematic Representation Of Hypothalamus-pituitary-mentioningconfidence: 97%“…Although numerous mathematical models [26-28] and the involvement of genetic factors [29] have been proposed, there are few experimental systems that enable us to explore the molecular mechanism underlying this unique relationship between them. GATA2 is expressed not only in thyrotroph but also in gonadotroph [2,3,30] and placenta [31][32][33], resulting in the potentiation of the CGA gene expression [34,35]. Using trophoblast stem cell line, Rcho-1, and TS cells, Ray et al [36] surveyed approximately 100-kb regions of the rat and mouse GATA loci using quantitative chromatin immunoprecipitation (ChIP) assay. …”mentioningconfidence: 99%

VSports最新版本 - Liganded T3 receptor β2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production

Hirahara1, Nakamura2, Sasaki3 et al. 2020PLoS ONE6040Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1 VSports app下载. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.