Intestinal Alkaline Phosphatase Attenuates Alcohol-Induced Hepatosteatosis in Mice

Intestinal alkaline phosphatase targets the gut barrier to prevent aging

Kühn1, Adiliaghdam2, Cavallaro3 et al. 2020JCI InsightSelf Cite10141100Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…Aged vervet monkeys exhibit reduced intestinal barrier function, leading to increased microbial translocation associated with systemic inflammation (28). Independently of aging, we have previously shown that IAP can protect the host from potentially harmful gut-derived mediators via promoting gut barrier integrity and regulation of tight junction proteins in vitro and in vivo (9,10,15,29). In vitro, overexpression of IAP in intestinal epithelial cells (Caco-2 and T84) resulted in significant increases in the mRNA levels of the tight junction proteins ZO-1 and ZO-2 (9). …”Section: Discussionmentioningconfidence: 99%

Intestinal alkaline phosphatase targets the gut barrier to prevent aging

Kühn1, Adiliaghdam2, Cavallaro3 et al. 2020JCI InsightSelf Cite10141100Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…These high levels promote leaky gut with translocation of bacterial products, triggering inflammatory and adaptative host immune responses. Gut microbiota and enterocytes metabolize alcohol through enzymes, such as alcohol dehydrogenase, into by‐products, such as acetaldehyde . Once alcohol reaches the liver it is also metabolized, and the liver can upregulate its metabolic pathways to adapt to higher concentrations …”Section: Introductionmentioningconfidence: 99%

Gut microbiota in non‐alcoholic fatty liver disease and alcohol‐related liver disease: Current concepts and perspectives

Arab1, Arrese2, Shah3 2020Hepatology Research562410Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…IAP concentrations in the stools of entire healthy control and IHD populations are shown in Figure 1. Compared to healthy controls, IHD patients have approximately 29. 5% less IAP (mean ± SEM: 63:8 ± 3:5 vs. 44:9 ± 2:1 U/g stool, respectively; p = 0:000001; median (range): 44 however, the difference is not significant (p = 0:087223). Similarly, the IHD males have 13. 0% lower IAP level compared to IHD females, and the difference is not statistically significant (p = 0:140301). …”Section: Disease Markersmentioningconfidence: 85%“…that have toxic effect on bacterial growth [42]. Also, IAP limits fat absorption and maintains the gut mucosal integrity [43,44] VSports app下载. …”mentioningconfidence: 99%

Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease

Malo1, Alam2, Shahnaz3 et al. 2019Disease MarkersSelf Cite90130Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.