Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages

"V体育2025版" Caspase‐11 non‐canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage‐mediated inflammatory responses

Yi1 2017Immunology21722490Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Interestingly, GSDMD did not affect the maturation of either caspase-11 or IL-1b, 75 suggesting that GSDMD is downstream of caspase-1 and only aids in the induction of pyroptosis and the secretion of IL-1b during the caspase-11 non-canonical inflammasome response. 76 More direct evidence that GSDMD generates pores during the caspase-11 non-canonical inflammasome response have been reported. Ding et al 77 expressed and purified the N-terminal fragments of GSDMD and demonstrated that the purified N-terminal fragments of GSDMD lysed phosphoinositide/cardiolipin-containing liposomes and formed structurally stable pores with a diameter of 10-14 nm and 17 symmetric protomers on the artificial and natural phospholipid membranes. …”Section: Gasdermin D Is a Key Molecule In Caspase-11 Noncanonical Infmentioningconfidence: 97%“…reported that the N‐terminal fragment of GSDMD processed by caspase‐1 was essential for pyroptosis and IL‐1 β secretion, which were abolished in Gsdmd −/− Raw264 VSports app下载. 7 cells. Interestingly, GSDMD did not affect the maturation of either caspase‐11 or IL‐1 β , suggesting that GSDMD is downstream of caspase‐1 and only aids in the induction of pyroptosis and the secretion of IL‐1 β during the caspase‐11 non‐canonical inflammasome response . More direct evidence that GSDMD generates pores during the caspase‐11 non‐canonical inflammasome response have been reported. …”Section: Non‐canonical Inflammasome Activation During Inflammatory Rementioningconfidence: 99%

Caspase‐11 non‐canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage‐mediated inflammatory responses

Yi1 2017Immunology21722490Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…A recent study has shown that inhibition of serine peptidases DPP8 and DPP9 leads to activation of caspase‐1, cleavage of gasdermin D, and pyroptosis . However, in response to classic apoptotic signals, activated caspase‐3 and ‐7 cleave gasdermin D at residue D87, a different site to that cleaved by inflammatory caspases . The resultant p45 gasdermin D fragment is inactive and cannot engage pyroptosis, allowing apoptosis to ensue …”Section: Gasderminmentioningconfidence: 99%

Molecular mechanisms of inflammasome signaling

Mathur1, Hayward2, Man3 2017Journal of Leukocyte Biology17111330Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Pyroptosis is mainly characterized by cell membrane rupture and DNA damage [19], as shown by TUNEL staining in the current study. A previous study found cell apoptosis in the contralateral kidneys of UUO; however, it may because the apoptosis and pyroptosis signaling pathways have bilateral crosstalk [20]. The latest data indicate that pyroptosis has played an important part in some kidney diseases, such as Ald-salt-treated rats and ischemia-reperfusion kidney injury [8,21]. …”Section: Discussionmentioningconfidence: 99%

Eplerenone Ameliorates Cell Pyroptosis in Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction

Ma1, Chang2, Xiong3 et al. 2019Nephron150100Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.