V体育官网 - Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii Shows a Protective Effect on DNBS and DSS-Induced Colitis Model in Mice through Inhibition of NF-κB Pathway

VSports app下载. Our results suggest that MAM potentially modulates numerous biological processes and signaling pathways of the intestinal epithelium. …”Section: Discussionmentioningconfidence: 99%See 1 more Smart Citation

Faecalibacterium prausnitzii‐derived microbial anti‐inflammatory molecule regulates intestinal integrity in diabetes mellitus mice via modulating tight junction protein expression

Xu1, Liang2, Zhang3 et al. 2019Journal of Diabetes16661070Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Interestingly, the results indicated that F. prausnitzii supernatant potentially regulates cell‐cell adhesion and the tight junction pathway, which are key to the intestinal barrier integrity. MAM, a newly discovered protein product of F. prausnitzii , shows anti‐inflammatory effects in the intestine in IBD . We questioned whether MAM could act on the intestinal barrier. …”Section: Discussionmentioningconfidence: 99%“…MAM, a newly discovered protein product of F. prausnitzii, shows anti-inflammatory effects in the intestine in IBD. 22,39 We questioned whether MAM could act on the intestinal barrier. Our results suggest that MAM potentially modulates numerous biological processes and signaling pathways of the intestinal epithelium. …”Section: Discussionmentioningconfidence: 99%

Faecalibacterium prausnitzii‐derived microbial anti‐inflammatory molecule regulates intestinal integrity in diabetes mellitus mice via modulating tight junction protein expression

Xu1, Liang2, Zhang3 et al. 2019Journal of Diabetes16661070Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Tregs are abundant in the intestinal mucosa and are also modulated directly by bacterial antigens. For example, Faecalibacterium prausnitzii and Bacteroides fragilis, both common gut commensals, induced Treg activation and differentiation via the surface proteins, microbial anti-inflammatory molecule (MAM) and polysaccharide A (PSA), respectively (14,15). Both F. prausnitzii and B. fragilis are often missing or present at low abundancy in patients with IBD (16). …”Section: Regulatory T Cells (Tregs)mentioningconfidence: 99%

Intestinal Organoids as a Tool for Inflammatory Bowel Disease Research

Angus1, Butt2, Schultz3 et al. 2020Front. Med. 601450Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…92,93 In accordance with this, Quévrain et al 94 identified a 15 kDa anti-inflammatory protein was secreted by F. prausnitzii. Subsequently, a study by Breyner et al 95 demonstrated F. prausnitzii secreted peptides termed "microbial anti-inflammatory molecules" can inhibit nuclear factor (NF)-κB promoter activity and interleukin (IL)-6 production, leading to protection from experimental colitis in mice through alteration of T cell immune responses. Interestingly, co-culture studies have demonstrated F. prausnitzii does not enhance barrier function but can induce activation of NF-κB signaling downstream of IL-1β in Caco-2 cells. …”Section: Faecalibacterium Prausnitziimentioningconfidence: 99%

Epithelial-microbial diplomacy: escalating border tensions drive inflammation in inflammatory bowel disease

King1, McCole2 2019Intest Res172100Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.