IL-15 Enables Septic Shock by Maintaining NK Cell Integrity and Function

The biology of natural killer cells during sepsis

Guo1, Patil2, Luan3 et al. 2017ImmunologySelf Cite11821141Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In a previous study from our laboratory, overdose of IL‐15 caused sepsis‐like inflammatory pathology and mortality via hyperproliferation of activated NK cells and hyperproduction of IFN‐ γ . In another study from our group, IL‐15‐deficient mice, which lack NK cells, exhibited improved survival, attenuated hypothermia, and less pro‐inflammatory cytokine production during septic shock caused by caecal ligation and puncture or endotoxin‐induced shock . IL‐15 superagonist (IL‐15SA, IL‐15/IL‐15Ra complex) regenerated NK cells and re‐established mortality of IL‐15 knockout mice during septic shock, while preventing NK cell regeneration attenuated the restoration of mortality caused by IL‐15SA. …”Section: Nk Cells: Friend or Foe During Sepsis. mentioningconfidence: 92%“…As noted above, early work identified IL‐15 as a co‐regulator of LPS‐induced shock VSports app下载. Our group investigated the role of IL‐15 in more detail and discovered that IL‐15 enables the pathogenesis of septic shock by maintaining and activating NK cells . IL‐15 is a small cytokine molecule essential for the development and differentiation of NK cells . …”Section: Nk Cells: Friend or Foe During Sepsis. mentioningconfidence: 99%“…Our group investigated the role of IL-15 in more detail and discovered that IL-15 enables the pathogenesis of septic shock by maintaining and activating NK cells. 86 IL-15 is a small cytokine molecule essential for the development and differentiation of NK cells. 87 In a previous study from our laboratory, overdose of IL-15 caused sepsis-like inflammatory pathology and mortality via hyperproliferation of activated NK cells and hyperproduction of IFN-c. 88 In another study from our group, IL-15-deficient mice, which lack NK cells, exhibited improved survival, attenuated hypothermia, and less pro-inflammatory cytokine production during septic shock caused by caecal ligation and puncture or endotoxin-induced shock. …”Section: Detrimental Role Of Nk Cells During Experimental Sepsismentioningconfidence: 99%“…87 In a previous study from our laboratory, overdose of IL-15 caused sepsis-like inflammatory pathology and mortality via hyperproliferation of activated NK cells and hyperproduction of IFN-c. 88 In another study from our group, IL-15-deficient mice, which lack NK cells, exhibited improved survival, attenuated hypothermia, and less pro-inflammatory cytokine production during septic shock caused by caecal ligation and puncture or endotoxin-induced shock. 86 use of IL-15-neutralizing IgG M96 in wild-type mice. If given immediately before septic challenge, M96 failed to deplete NK cells and did not protect against septic shock. …”Section: Detrimental Role Of Nk Cells During Experimental Sepsismentioningconfidence: 99%See 2 more Smart Citations

"V体育官网入口" The biology of natural killer cells during sepsis

Guo1, Patil2, Luan3 et al. 2017ImmunologySelf Cite11821141Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…As IL-15 is heavily involved in autoimmune and chronic inflammatory diseases (80–82), IL-15 superagonist may also elicit dangerous pro-inflammatory signaling in chronic settings. Furthermore, IL-15 superagonist treatment has been shown to aggravate septic shock, in which hosts develop overwhelming pro-inflammatory responses to infections during the acute phase, through NK cell activation and IFN-γ production (83–88). Considering that people with cancer are particularly susceptible to developing sepsis compared to the general population (89, 90), IL-15 superagonist should be used with caution as it advances through drug development for cancer patients with complications of sepsis. …”Section: Il-15 Superagonist Toxicitymentioningconfidence: 99%

Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent

Guo1, Luan2, Patil3 et al. 2017Cytokine & Growth Factor ReviewsSelf Cite13611100Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

A shift toward inhibitory receptors and impaired effector functions on NK cells contribute to immunosuppression during sepsis

Feng1, Liao2, Yang3 et al. 2019Journal of Leukocyte Biology273240Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.