"V体育平台登录" Patterns of diagnostic marker assessment in adult diffuse glioma: a survey of the European Confederation of Neuropathological Societies (Euro-CNS)

"VSports app下载" The Role of ATRX in Glioma Biology

Nandakumar1, Mansouri2, Das3 2017Front. Oncol. 1121801Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Practical hurdles are foreseeable with the use of molecular diagnostics. Although with its updated classification of CNS tumors WHO has tried to implement a consensus on diagnostic practices worldwide, there still remains a lack of guidelines on which molecular techniques to use ( 62 ). With the addition of many clinically relevant biomarkers, a major challenge is the limited amount of tissue available for molecular tests; therefore, there lies a need for the advancement of technology that can perform multiplexed/global profiling for simultaneous tests of various biomarkers ( 63 ). …”Section: Future Directionsmentioningconfidence: 99%“…Formalin-fixed paraffin-embedded tissue (FFPE) remains as a popular method of tissue processing; however, biosample processing also needs to be updated to adhere for future applications of molecular diagnostics as currently FFPE degrades proteins for standard analysis ( 63 ). A survey among members of the European Confederation of Neuropathological Societies revealed heterogeneity within and between countries with regard to access to molecular diagnostics, molecular techniques, and laboratory practices, with low-income countries reporting to use fewer biomarkers in diagnostic tests ( 62 ). …”Section: Future Directionsmentioningconfidence: 99%“…The newly proposed integrative approach includes other technical challenges as well, including training laboratory personnel with molecular testing, acquiring skills to interpret the combined information from traditional tests and molecular pathology, assuring reliability, reproducibility, and quality control of molecular testing, treatment difficulties with those patients who have been diagnosed with uncertain NOS (not otherwise specified) gliomas and increased costs for the new generation of technology ( 64 , 65 ). Hence, huge changes to existing infrastructures and resources are foreseeable to bring about equal access to molecular diagnostics worldwide, which includes creating new regulating and accreditation agencies to ensure quality and competence of laboratories, setting up standardized procedures, references, and testing software, generation of health-care schemes and insurance policies for equal coverage of these tests, determining ethical bindings and a need for higher understanding of pathology informatics so that the multitude of data generated from molecular tests can be transformed into pathology reports relevant for clinical needs ( 62 , 65 , 66 ). …”Section: Future Directionsmentioningconfidence: 99%See 1 more Smart Citation

"V体育官网" The Role of ATRX in Glioma Biology

Nandakumar1, Mansouri2, Das3 2017Front. Oncol. 1121801Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Many of these diagnostic biomarkers also serve as prognostic indicators, and the neuro-oncology community has supported this integration of molecular markers into clinical practice [6]. However, to date, there is wide variability in biomarker assessment because molecular techniques and test validity are inconsistent throughout the world and even within geographic regions [7,8]. Therefore, the use of novel sequencing techniques that can assess multiple biomarkers simultaneously is an attractive option to overcome current clinical practice limitations. …”Section: Introductionmentioningconfidence: 99%

A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma

Wongsurawat1, Jenjaroenpun2, Loose3 et al. 2020acta neuropathol commun401440Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…With regard to the applied methodology, it is left open which methods and criteria are used for molecular testing in the respective laboratory. Concerns, however, remain with regard to interlaboratory comparability and robustness of molecular test results [ 11 ]. This problem may be less eminent in case of IDH mutation, because the most frequent IDH mutation (R132H) can be immunohistochemically visualized by means of a mutation-specific antibody, which has been shown to yield reliable and reproducible test results [ 12 ]. …”Section: Introductionmentioningconfidence: 99%

Molecular diagnostic testing of diffuse gliomas in the real-life setting: A practical approach

Bieńkowski1, Wöhrer2, Moser3 et al. 2018NPSelf Cite10070Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.