Regulation and plasticity of intestinal stem cells during homeostasis and regeneration (VSports最新版本)

Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells

Jaeckel1, Kaller2, Jackstadt3 et al. 2018Nat Commun211220Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…10Model summarizing the results of this study. The results are explained in the context of the previously described biology of the intestinal crypt: The homeostasis of the intestinal epithelium is regulated by the Wnt/β-catenin and Notch pathways, which control stem cell maintenance and differentiation 16,17 . In the small intestine, the crypt base harbors 4–6 intestinal stem cells (ISCs), which are surrounded by supporting Paneth cells. …”Section: Discussionmentioningconfidence: 75%“…These signatures also showed preferential enrichment among the mRNAs downregulated after deletion of Ap4 . Moreover, mRNAs encoding for proteins involved in Wnt/β-catenin and Notch signaling, which control the homeostasis of ISCs 16,17 , were also preferentially downregulated in Ap4 -deficient adenomas (Fig. 4a, b, Supplementary Fig. …”Section: Resultsmentioningconfidence: 99%

Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells

Jaeckel1, Kaller2, Jackstadt3 et al. 2018Nat Commun211220Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Thus, for example, both scale and interscale tail skin progenitors participate in re-epithelialization following a punch wound, but only the EpdSCs in the compartment closest to the wound site appear to contribute long term (Mascre et al, 2012; Sada et al, 2016) (Figure 5). Examples of such wound-induced plasticity in epithelial progenitors now abound, being described not only for the skin epidermis but also the sweat gland (Lu et al, 2012) and intestinal epithelium (reviewed by Beumer and Clevers, 2016). By essentially making an emergency “911” call to all nearby progenitors in the vicinity of the wound, optimal restoration of epithelial barriers is ensured. …”Section: Contribution and Dynamics Of Skin Stem Cells During Homeostamentioningconfidence: 99%

V体育ios版 - Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche

Gonzales1, Fuchs2 2017Developmental Cell39753620Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Intestinal stem cells (ISCs) in the crypts maintain and repair the epithelial surface by giving rise to differentiated cells on the villi. Differentiation of ISCs in the crypts produces daughter cells that migrate up in a “conveyer belt” fashion to the villi, where they mature into both absorptive and secretory cells that play a major role in nutrient absorption and other intestinal functions (Potten, 1997; van der Flier and Clevers, 2009; Mezoff and Shroyer, 2015; Henning and von Furstenberg, 2016; Beumer and Clevers, 2016). One exception to this migratory pathway is the mature Paneth cells, which remain in the crypts instead of migrating upward, interact closely with the ISCs, and secrete stem cell maintenance factors, including WNT (Henning and von Furstenberg, 2016; Mezoff and Shroyer, 2015; Beumer and Clevers, 2016). …”Section: Introductionmentioningconfidence: 99%“…The crypts are thought to contain two types of ISCs (Henning and von Furstenberg, 2016; Mezoff and Shroyer, 2015; Beumer and Clevers, 2016). The best studied is the crypt-based columnar cells (CBCs) located at the base of the crypt. …”Section: Introductionmentioningconfidence: 99%

Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation

Zou1, Blutt2, Zeng3 et al. 2018Cell Reports692560Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.