"VSports注册入口" Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery

Antigen-specific regulatory T-cell responses to intestinal microbiota (V体育ios版)

Russler-Germain1, Rengarajan2, Hsieh3 2017Mucosal Immunology1082990Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…TCR Tg cells from these two lines did not undergo Treg cell induction upon transfer in young mice, but only in mice around the age of weaning or thereafter 33 . This was due to the lack of the appropriate bacteria in young mice, rather than an immature immune compartment incapable of inducing Treg cell selection, as fecal microbiota transplant from three-, but not one-, week old donors into one-week old recipients was sufficient to induce Treg cell development. …”Section: Developmental Origin Of Colonic Treg Cellsmentioningconfidence: 89%“…The conclusions may also be affected by the different TCRβ chains used 26, 36 or the use of a limited TCRα/fixed TCRβ model 26 , as effects on Treg cell selection has been reported for changes in a single TCR chain (TCRα 37 ). The ability of two of these colonic TCRs (CT2/CT6) to facilitate pTreg cell induction from naïve T cells in the periphery in normal mice was confirmed via the generation of transgenic (Tg) lines 33 . Altogether, these data suggest that the majority of colonic Treg cells arise via pTreg cell differentiation from naïve T cells. …”Section: Developmental Origin Of Colonic Treg Cellsmentioningconfidence: 97%“…High expression of the transcription factor Helios and cell surface protein Nrp-1 have been associated with tTreg cells 27-29 . Although the utility of these markers remains controversial 30-32 , colon lamina propria (cLP) Treg cells contain a much lower proportion of pTreg cells in germ-free compared with SPF mice based on these markers 22, 27-29, 33 . In addition, treatment of SPF mice with broad-spectrum antibiotics results in the loss of cLP pTreg cells based on Helios levels 22 . …”Section: Developmental Origin Of Colonic Treg Cellsmentioningconfidence: 99%“…Our group has used colon Treg TCR Tg lines to study the process of pTreg cell differentiation to commensal bacterial antigens 33 . Using adoptive transfer of peripheral naïve T cells from CT2/CT6 TCR Tg mice into wild type, lymphoreplete mice, it was found that pTreg cell generation was very efficient and resulted in over 80% of cells in the colon and mesenteric lymph nodes upregulating Foxp3 by three weeks after transfer. …”Section: Developmental Origin Of Colonic Treg Cellsmentioningconfidence: 99%“…The time-period around weaning is associated with major changes in the composition of the intestinal microbiota due to the switch to solid food and acquisition of a more adult-like microbiota 44 . In fact, studies using Helios and Nrp-1 to identify Treg cell origin show a marked shift in the colon from tTreg to pTreg cells around weaning 22, 23, 27, 33, 36 . In summary, there is now a substantial body of work supporting the notion that the majority of colonic Treg cells are generated by pTreg cell selection in response to colonic bacteria acquired around weaning. …”Section: Developmental Origin Of Colonic Treg Cellsmentioningconfidence: 99%See 3 more Smart Citations

Antigen-specific regulatory T-cell responses to intestinal microbiota

Russler-Germain1, Rengarajan2, Hsieh3 2017Mucosal Immunology1082990Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

Xie1, Du2, Lu3 et al. 2025Advanced Science1000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

Tissue adaptation of regulatory T cells in adipose tissue

Yu1, Bai2, Wu3 et al. 2022Eur J Immunol8030Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.