"VSports" The integrated stress response

VSports app下载. Plasmodium activates the parasitic ISR by phosphorylating eIF2α in response to diverse cell perturbations, including stress induced by drugs such as ART or chloroquine (Surolia and Padmanaban, 1991), or amino acid deprivation (Babbitt et al, 2012; Fennell et al, 2009). …”Section: Discussionmentioningconfidence: 99%

VSports最新版本 - Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency

Zhang1, Gallego‐Delgado2, Fernández-Arias3 et al. 2017Cell Host & Microbe130161801Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The ISR centers on the ability of cells to modulate translation of mRNAs through the phosphorylation of eIF2α. Severe or prolonged stress will overwhelm the capacity of the adaptive response and initiate cell death (Pakos-Zebrucka et al, 2016). Plasmodium activates the parasitic ISR by phosphorylating eIF2α in response to diverse cell perturbations, including stress induced by drugs such as ART or chloroquine (Surolia and Padmanaban, 1991), or amino acid deprivation (Babbitt et al, 2012; Fennell et al, 2009). …”Section: Discussionmentioningconfidence: 99%

Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency

Zhang1, Gallego‐Delgado2, Fernández-Arias3 et al. 2017Cell Host & Microbe130161801Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Integrated Stress Response (ISR) is an integral part of cellular responses to diverse stresses including those affecting the ER. During acute/transient ER stress, first ISR program encompasses PERK kinase-driven translational reprogramming caused by phosphorylation of the translation initiation factor eIF2α subunit 4 (eIF2α-P) and inhibition of eIF2B guanine nucleotide exchange factor (GEF) activity (Pakos-Zebrucka et al, 2016). This attenuates eIF2 and ternary complex (TC) recycling, impedes initiator Met-tRNAi Met delivery, and reduces global translation (Hinnebusch, 2014; Sonenberg and Hinnebusch, 2009). …”Section: Introductionmentioningconfidence: 99%“…This allows efficient translation of mRNAs that were transcriptionally induced, while shutting down translation of the uORF-containing mRNAs. Restoration of eIF2B GEF activity and protein synthesis signifies termination of the acute ER stress response (Pakos-Zebrucka et al, 2016). The UPR also involves two ISR-independent arms whereby the transcription factors XBP1s and ATF6 increase expression of genes involved in proteostasis. …”Section: Introductionmentioningconfidence: 99%

A Unique ISR Program Determines Cellular Responses to Chronic Stress

Guan1, Hoef2, Jobava3 et al. 2017Molecular Cell187272704Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In mammals, the ISR is triggered by a family of kinases with a shared substrate; namely, the alpha subunit of eukaryotic initiation factor 2 (eIF2). Phosphorylation of eIF2 at serine 51 leads to global and gene-specific changes in translation which, depending on the timing and intensity of the stress, direct the cell/tissue/organism toward adaptation or cell death (1). …”Section: Introductionmentioningconfidence: 99%

Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver

Nikonorova1, Mirek2, Signore3 et al. 2018Journal of Biological Chemistry502520Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Scite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.