Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice

Roles of High Mobility Group Box 1 in Cardiovascular Calcification

Chen1, Wang2, Chen3 et al. 2017Cell Physiol Biochem222150Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In the extracellular environment, HMGB1 regulates inflammation as well as cell proliferation, survival and migration upon interaction with high-affinity receptors including receptor of advanced glycation end-products (RAGE), Toll-like receptors (TLRs) 2, -4, and -9, CXCR4, macrophage antigen-1, syndecan-3, CD24-Siglec-10, and T cell Igmucin-3 [9, 21, 34]. The role of HMGB1 has been investigated in several systemic disorders, including sepsis, cancer, kidney diseases [36], thrombosis [37, 38], and certain autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) [9, 33, 34]. HMGB1 is also a critical mediator in vascular diseases [39] such as atherosclerosis [35, 40, 41], myocardial ischemia/reperfusion (I/R) injury [42, 43], heart failure [44, 45], acute coronary syndrome (ACS) [46, 47], vasculitis [34], pulmonary artery disease [48-50], cerebral artery disease [51-53], and peripheral artery diseases (PADs) [54, 55]. …”Section: The Basic Actions Of Hmgb1mentioningconfidence: 99%

Roles of High Mobility Group Box 1 in Cardiovascular Calcification

Chen1, Wang2, Chen3 et al. 2017Cell Physiol Biochem222150Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In a previous study, we observed elevated HMGB1 expression levels on circulating platelets in patients with trauma and hemorrhagic shock, and identified platelet-derived HMGB1 as a critical mediator of thrombosis [9]. Another study has confirmed a critical prothrombotic role of platelet-derived HMGB1 in a mouse model of venous thrombosis [18]. Although coronary thrombus formation undoubtedly plays an important role in the pathophysiology of myocardial infarction [14], the potential impact of HMGB1 expressed on the surface of circulating platelets on heart attack is unclear and debatable. …”Section: Discussionmentioningconfidence: 90%

HMGB1 Expression Level in Circulating Platelets is not Significantly Associated with Outcomes in Symptomatic Coronary Artery Disease

Rath1, Geisler2, Gawaz3 et al. 2017Cell Physiol Biochem11030Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Also, recombinant human soluble thrombomodulin protected against CVST via the inhibition of HMGB-1 [101]. Further, platelet-derived disulfide HMGB-1 contributed to venous thrombosis as a central mediator of the sterile inflammatory process [16]. …”Section: Figmentioningconfidence: 99%“…Blockade of extracellular HMGB-1 attenuated inflammation and coagulation abnormalities in traumatic coagulopathy models [119], suggesting that HMGB-1 could promote thrombosis via sterile inflammation. Reduced HMGB-1 on the surface upon activation induced the recruitment of monocytes, and active leukocytes in turn promoted the Cellular Physiology and Biochemistry Cellular Physiology and Biochemistry oxidation of HMGB-1, unleashing its prothrombotic activity [16]. Thus, sterile inflammation may be vital in HMGB-1-induced thrombosis. …”Section: Hmgb-1 and Netsmentioningconfidence: 99%“…The interaction between HMGB-1 and its receptors has been shown to induce cell adhesion [32], permeability [33,34], chemotaxis [35], inflammation [36][37][38], autophagy [39][40][41], apoptosis [42][43][44], thrombosis [16,45,46], angiogenesis [47,48], fibrosis [49,50], and epithelialmesenchymal transition (EMT) [51,52]. Although the exact mechanisms involved in the progression still remain unclear, myeloid differentiation factor 88 (MyD88)-mediated pathways have been the most studied. …”Section: Figmentioningconfidence: 99%See 1 more Smart Citation

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

Wu1, Li2, Pei3 et al. 2018Cell Physiol Biochem420260Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.