Global intron retention mediated gene regulation during CD4^{V体育2025版 - +}T cell activation

The Y Chromosome Modulates Splicing and Sex-Biased Intron Retention Rates in Drosophila

Wang1, Branco2, Lemos3 2018Genetics203160Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Recent studies have identified numerous differentially regulated AS events in a variety of conditions (MCINTYRE et al 2006;WANG et al 2008;TELONIS-SCOTT et al 2009;GAN et al 2010;CHANG et al 2011;HARTMANN et al 2011;STURGILL et al 2013;WANG et al 2014) and highlighted the role of IR as a cellular mechanism to influence mRNA abundance and alter biological outcomes (BRAUNSCHWEIG et al 2014;JUNG et al 2015;EDWARDS et al 2016;MAUGER et al 2016;NI et al 2016;MIDDLETON et al 2017;NARO et al 2017). However, the occurrence and extent of sex-biased IR has not been addressed and the role of sex chromosomes in the modulation of splicing has not been investigated. …”Section: Discussionmentioningconfidence: 99%“…Because of this, mRNAs generated through IR events could be viewed as failures of the splicing process and void of biological function (JAILLON et al 2008;ROY AND IRIMIA 2008). However, recent studies suggested that IR events are involved in multiple cellular and physiological processes, including hematogenesis (WONG et al 2013;EDWARDS et al 2016;PIMENTEL et al 2016), T cell activation (NI et al 2016), neuronal differentiation (BRAUNSCHWEIG et al 2014), and carcinogenesis (DVINGE AND BRADLEY 2015;JUNG et al 2015). Despite these advances, questions remain regarding the extent to which introns are differentially retained between sexes and how sex-biased IR rates are regulated. …”Section: Introductionmentioningconfidence: 99%

The Y Chromosome Modulates Splicing and Sex-Biased Intron Retention Rates in Drosophila

Wang1, Branco2, Lemos3 2018Genetics203160Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In contrast, four gene classes not needed until later in T-cell responses, such as late effector and memory T-cell function, were found in LADs as frequently as the whole genome and were mostly transcriptionally repressed. These relationships are largely maintained when instead considering published expression data from naïve CD4 + T cells (Supplemental Fig. S2C; Ni et al 2016). However, two of the five gene classes depleted from LADs and expressed in resting Jurkat T cells-active cell division and short-term effector functions-were not expressed in naïve CD4 + T cells (Supplemental Fig. …”Section: Gene Expression and Function Reflects Lamina-association Frementioningconfidence: 91%

Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments

Robson1, Heras2, Czapiewski3 et al. 2017Genome Res. 1097870Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Reducing the transcriptional burden by inhibiting RNAPII phosphorylation rescued splicing, suggesting that competition for the spliceosome selects weak introns for retention. Although IR was generally shown to cause transcript instability in mammals, thus contributing to the quenching of gene expression during cell differentiation or in response to stress (Yap et al. , 2012, Wong et al. , 2013, Shalgi et al. , 2014, Edwards et al. , 2016, Pimentel et al. , 2016, Ni et al. , 2016), we found that meiotic intron-retaining transcripts (IRTs) are long-lived mRNAs, which are preserved until they need to be translated. Thus, our study reveals an unexpected physiological role for IR in ensuring proper and timely control of gene expression during male germ cell differentiation. …”Section: Introductionmentioningconfidence: 99%

An Orchestrated Intron Retention Program in Meiosis Controls Timely Usage of Transcripts during Germ Cell Differentiation

Naro1, Jolly2, Persio3 et al. 2017Developmental Cell166181851Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC) VSports app下载. Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.