Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Elimination of p19^ARF‐expressing cells protects against pulmonary emphysema in mice

Mikawa1, Suzuki2, Baskoro3 et al. 2018Aging Cell397503Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The senolytic activities and efficacies of some drugs have already been confirmed in mouse disease models (Childs et al, 2016; Farr et al, 2017; Jeon et al, 2017; Ogrodnik et al, 2017; Roos et al, 2016; Schafer et al, 2017). We used the anti‐apoptotic Bcl‐2 family inhibitor, ABT‐263, in the PPE‐induced emphysema model. …”Section: Discussionmentioningconfidence: 94%“…The efficacy of drugs that induce senescent cell death, namely senolytic drugs, has been demonstrated in several mouse disease models. The combination of dasatinib and quercetin, which inhibits pro‐survival kinase pathways, ameliorates cardiovascular and vasomotor functions (Roos et al, 2016; Zhu et al, 2015), hepatic steatosis (Ogrodnik et al, 2017), and IPF (Schafer et al, 2017), similar to the semi‐genetic elimination of senescent cells. The anti‐apoptotic bcl‐2 family protein inhibitors ABT‐263/737 are effective in atherosclerosis and osteoarthritis models (Childs et al, 2016; Jeon et al, 2017) and improve stem cell functions and other aging‐associated phenotypes (Chang et al, 2016; Yosef et al, 2016). …”Section: Introductionmentioningconfidence: 99%

Elimination of p19^ARF‐expressing cells protects against pulmonary emphysema in mice

Mikawa1, Suzuki2, Baskoro3 et al. 2018Aging Cell397503Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Considering these findings, we sorted LepR + MSPCs from aging mice using flow cytometry and observed that LepR + MSPCs also displayed a senescent phenotype with decreased BrdU labelling, which confirmed the increased cellular senescence of LepR + MSPCs in aging bone marrow. The elimination of SnCs and inhibition of a certain SASP improves cardiovascular function (Roos et al. , 2016), enhances insulin sensitivity (Xu, Palmer et al. , 2015) and reduces frailty; (Xu, Tchkonia et al. , 2015). Several recent studies have targeted local elimination of SnCs as a treatment for bone degenerative diseases, such as osteoarthritis and osteoporosis (Farr et al. , 2017; Jeon et al. , 2017). …”Section: Discussionmentioningconfidence: 99%

Local delivery of tetramethylpyrazine eliminates the senescent phenotype of bone marrow mesenchymal stromal cells and creates an anti‐inflammatory and angiogenic environment in aging mice

Gao1, Lin2, Jing3 et al. 2018Aging Cell601400Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Senescent cells have been demonstrated to disrupt tissue structure and function through the secretion of pro‐inflammatory cytokines, chemokines, and proteases, a feature termed the senescence‐associated secretory phenotype (Campisi & d'Adda, 2007; Vicente, Mausset‐Bonnefont, Jorgensen, Louis‐Plence, & Brondello, 2016). Recent studies have demonstrated that selectively eliminating senescent cells can attenuate several age‐dependent disorders (Baker et al. , 2011; Chang et al. , 2016; Roos et al. , 2016; Zhu et al. , 2015). The relationship between autophagy and senescence is still subject to debate (Kang & Elledge, 2016). …”Section: Discussionmentioningconfidence: 99%

Young plasma reverses age‐dependent alterations in hepatic function through the restoration of autophagy

Liu1, Guo2, Yang3 et al. 2017Aging Cell634570Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.