Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

Inflammasomes and its importance in viral infections

Shrivastava1, León‐Juárez2, García‐Cordero3 et al. 2016Immunol Res12841220Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Furthermore, pyroptosis, which is associated with a highly inflammatory state induced by intracellular pathogens, has been reported to possibly contribute to an inflammatory syndrome in vivo [115]. In the non-canonical inflammasome pathway, it has been demonstrated that upon intracellular lipopolysaccharide (LPS) stimulation, caspase-11 cleaves the pannexin-1 channel resulting in the release of ATP, which in turn activates P2X7 to induce cytotoxicity and pyroptosis [116,117]. Recent findings have suggested that the presence of cytosolic LPS dramatically decreases the threshold concentration of ATP necessary to drive the opening of the P2X7 channel, which allows the release of proinflammatory cytokines such as IL-1b. …”Section: Regulation Of Inflammasome Activity and Il-1b Secretion Pyromentioningconfidence: 99%“…This further leads to P2X7 forming a receptor pore, allowing it to respond to the nanomolar concentration of released ATP. During the course of pyroptosis, ATP mostly works as an autocrine signal that targets the cells primed with hypersensitive P2X7 channels (such as those in which cytosolic LPS were detected) [116]. In addition, pannexin-1 was suggested to be necessary for mediating IL-1b release due to caspase-11 activation triggered by pannexin-1-mediated K . …”Section: Regulation Of Inflammasome Activity and Il-1b Secretion Pyromentioningconfidence: 99%

Inflammasomes and its importance in viral infections

Shrivastava1, León‐Juárez2, García‐Cordero3 et al. 2016Immunol Res12841220Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Recently, Yang and collaborators presented data indicating that pannexin-1 and P2X7R are required for susceptibility to endotoxic shock in mice induced via the non-canonical inflammasome pathway [74]. However, how P2X7R regulates the caspase-11 activation and what the role of pannexin-1 is in this process is not known yet VSports app下载. …”Section: Discussionmentioningconfidence: 99%

POM-1 inhibits P2 receptors and exhibits anti-inflammatory effects in macrophages

Pimenta-dos-Reis1, Torres2, Quintana3 et al. 2017Purinergic Signalling13090Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Furthermore, although residues participating in oligomerization and membrane insertion were proposed, the structural basis of gasdermin-N pore formation remains to be fully elucidated. In addition to gasdermin, a cytotoxicity mediated by pannexin1-P2X7 was reported recently (Yang et al, 2015). Caspase-11-dependent cleavage of the pannexin-1 allows the release of ATP which further activates P2X7 to mediate pyroptosis. …”mentioningconfidence: 99%“…A crucial substrate of inflammatory caspases, gasdermin D (GSDMD), was independently identified by several groups in 2015 (He et al, 2015;Kayagaki et al, 2015;Shi et al, 2015). According to their results, GSDMD is cleaved by the activated caspases-1/4/5/11 between its N-terminal and C-terminal domains. …”mentioningconfidence: 99%

Gasdermins pore cell membrane to pyroptosis

Liang1, Liu2 2016Sci. China Life Sci. 190140Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Scite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.