"V体育官网" Loop recognition and copper-mediated disulfide reduction underpin metal site assembly of Cu _A in human cytochrome oxidase

"V体育ios版" Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module

Bourens1, Barrientos2 2017Journal of Biological Chemistry685600Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…According to Leary et al (26), based on studies in cultured human cells, SCO2 and then SCO1 successively transfer a copper ion to COX2, and subsequently SCO2 acts as a thiol-disulfide oxidoreductase for SCO1. However, a recent in vitro biochemical study (31) reported that SCO1 is a metallochaperone that selectively transfers Cu(I) ions based on loop recognition, whereas SCO2 is a copper-dependent thiol reductase of the Cu A cysteine ligands in COX2. Hence, in this scenario, the reduction of the apo-Cu A disulfide by SCO2 Cu(I) is carried out by the metal and not by the thiols. …”Section: Discussionmentioningconfidence: 99%

"VSports在线直播" Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module

Bourens1, Barrientos2 2017Journal of Biological Chemistry685600Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…49, 50 SCO1 was originally linked to copper delivery to COX through a high copy suppressor screen of a COX17 null yeast strain. 28 Its copper is coordinated via a Cx 3 C motif and a conserved histidine residue, 51–53 and is transferred directly to the Cu A site of COX2 54 in a reaction that also requires the COX assembly factors SCO2 and COA6 (Figure 1). 55–58 Interestingly, a multitude of other IMS-localized proteins containing canonical twin Cx 9 C motifs have been implicated in COX assembly in yeast, 59 many of which have evolutionarily conserved mammalian homologues with undefined functions. …”Section: Copper In Mitochondriamentioningconfidence: 99%“…45 This led us to propose a model whereby SCO2 acts upon SCO1 to modulate the generation of a mitochondrial signal that regulates the rate of copper efflux from the cell. 23, 45 Subsequent studies demonstrated that SCO2 possesses a thiol-disulphide oxidoreductase activity 54, 56 that may in fact allow it to regulate the generation of a redox signal by targeting the cysteines of the Cx 3 C motif of SCO1. The transduction of this signal at least in part requires COX19, a soluble COX assembly factor which partitions between mitochondria and the cytosol in a copper-dependent manner. …”Section: Mitochondrial Copper Chaperones Play a Key Role In The Regulmentioningconfidence: 99%

"V体育2025版" The mitochondrion: a central architect of copper homeostasis

Baker1, Cobine2, Leary3 2017Metallomics14911280Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Cu A site formation requires that copper is transferred from COX17 to SCO1, which subsequently catalyzes its insertion into COX2 (9). SCO2 appears to be essential for this latter copper transfer step because it acts as an oxidoreductase on the cysteinyl thiolates of COX2 (15,16). …”mentioningconfidence: 99%

"V体育2025版" The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis

Boulet1, Vest2, Maynard3 et al. 2018Journal of Biological Chemistry14181430Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1 VSports app下载. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.