Bile Salts Modulate the Mucin-Activated Type VI Secretion System of Pandemic Vibrio cholerae

VSports app下载. Because we found that SPI-6 is important for S. Typhimurium to colonize the guts of mice, we tested whether bile salts increase the activity of S. Typhimurium SPI-6 T6SS. …”Section: S Typhimurium T6ss Kills Microbiota Members and Is Enhanced Bymentioningconfidence: 98%See 1 more Smart Citation

VSports最新版本 - Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut

Sana1, Flaugnatti2, Lugo3 et al. 2016Proc. Natl. Acad. Sci. U. S. A. 326173560Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Finally, the antibacterial action of the S. Typhimurium SPI-6 T6SS within the gut is supported by the observation that killing of prey bacteria is enhanced in the presence of bile salts ( Fig. 2A), a result similar to that observed for mucin activation and bile salts activation of the V. cholerae T6SS within the mouse gut (41). …”Section: Discussionsupportingconfidence: 68%“…Thus, the pleiotropic effects that are associated with H-NS-deficient strains prohibit the use of the hns mutant for in vivo and ex vivo experiments, which prompted us to identify signal molecules that activate S. Typhimurium T6SS encoded on SPI-6. A previous study demonstrated that the T6SS from V. cholerae, an intestinal pathogen, is activated by bile salts (41). Because we found that SPI-6 is important for S. Typhimurium to colonize the guts of mice, we tested whether bile salts increase the activity of S. Typhimurium SPI-6 T6SS. …”Section: S Typhimurium T6ss Kills Microbiota Members and Is Enhanced Bymentioningconfidence: 98%

VSports注册入口 - Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut

Sana1, Flaugnatti2, Lugo3 et al. 2016Proc. Natl. Acad. Sci. U. S. A. 326173560Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In these cases, focusing on the host response pathways may expose cues for T6SS activation in eukaryotic settings [70 ]. Subsequent reproduction of such stimuli in vitro could then lead to the discovery of novel anti-host effectors that are otherwise difficult to identify. …”Section: Discussionmentioningconfidence: 99%

Type VI secretion and anti-host effectors

Hachani1, Wood2, Filloux3 2016Current Opinion in Microbiology26782230Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Indeed, T6SS was shown to be important in the infection of both mice and rabbits (51,52). It was recently shown that mucins, the main protein component of the mucus layer in the small intestine, which V. cholerae colonizes, are capable of causing this activation (53). Therefore, while pandemic isolates may not display constitutive contact-dependent bacterial killing, they can still upregulate this mechanism during colonization of both chitin in the environment and of the small intestine in a human host. …”Section: Discussionmentioningconfidence: 99%

V体育官网入口 - Diversity of Clinical and Environmental Isolates of Vibrio cholerae in Natural Transformation and Contact-Dependent Bacterial Killing Indicative of Type VI Secretion System Activity

Bernardy1, Turnsek2, Wilson3 et al. 2016Appl Environ Microbiol6810913Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.