cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response to Francisella Infection

"V体育官网" The Roles of Type I Interferon in Bacterial Infection

Boxx1, Cheng2 2016Cell Host & Microbe32272930Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Expression of genes in the Francisella pathogenicity island trigger the escape of the bacteria from the phagosome to the cytoplasm, and once in the cytoplasm the bacteria induce type I IFN through a cGAS- and IFI204-STING-IRF3 dependent pathways (Henry et al, 2007; Storek et al, 2015). Type I IFNs suppress the innate antibacterial response by inhibiting expression of IL-17A by γδ T cells. …”Section: Disparate Roles Of Type I Ifns During Bacterial Infectionmentioningconfidence: 99%“…As in Listeria infections, elevated expression of IL-17A in IFNAR1 deficient mice enhances splenic neutrophil recruitment and is correlated with both improved bacterial clearance and survival (Henry et al, 2010). Interestingly, though deficiency in cGAS, STING, IFNAR1 or IRF3 renders mice resistant to infection by Francisella (Henry et al, 2007; Storek et al, 2015), deletion of AIM2, an ALR induced by type I IFNs, is detrimental to host defense (Jones et al, 2010; Rathinam et al, 2010). Yet, while type I IFNs potentiate AIM2 expression and indirectly its antibacterial activity, simultaneously AIM2 suppresses induction of type I IFNs by negatively regulating the cGAS-STING-IRF3 pathway (Corrales et al, 2016). …”Section: Disparate Roles Of Type I Ifns During Bacterial Infectionmentioningconfidence: 99%

The Roles of Type I Interferon in Bacterial Infection

Boxx1, Cheng2 2016Cell Host & Microbe32272930Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…BMMo were differentiated in DMEM with 10% FBS and 20% MCSF and infected with F. novicida U112 and ΔFPI as previous described (65,66). Cytotoxicity was measured using LDH release (Promega, Madison, WI) and type I IFN levels were measured using ISRE-L929 reporter cells (67). …”Section: Plasmidsmentioningconfidence: 99%

VSports - LysMD3 is a type II membrane protein without an role in the response to a range of pathogens

Yokoyama1, Baldridge2, Leung3 et al. 2018Journal of Biological ChemistrySelf Cite131170Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task VSports app下载. “…Knockdown of mouse Ifi203 and mouse Ifi204 have been shown to dampen the IFN response to infection with multiple pathogens, including HSV-1, human immunodeficiency virus (HIV), murine leukemia virus (MLV), Francisella tularensis , and Mycobacterium tuberculosis (8, 38, 39). Despite these studies, a recent genetic study from Gray et al using mice lacking the entire PYHIN locus, lacking all 13 PYHIN genes, found that there was no change in the IFN signature when challenged with various immunostimulatory DNA ligands, DNA virus infection and lentivirus infection (23). …”Section: Discussionmentioningconfidence: 99%

V体育官网入口 - The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression

Ghosh1, Wallerath2, Covarrubias3 et al. 2017The Journal of Immunology200250Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.