Lung parenchyma-derived IL-6 promotes IL-17A–dependent acute lung injury after allogeneic stem cell transplantation (VSports手机版)

VSports app下载. [6][7][8][9][10][11][12] We have recently described Tc17 cytokine plasticity in murine allo-SCT recipients, 1 which is characteristic of a hyper-proinflammatory T-cell subset that contributes to GVHD but fails to mediate graft-versus-leukemia effects. …”Section: Introductionmentioningconfidence: 99%See 3 more Smart Citations

Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT

Gartlan1, Varelias2, Koyama3 et al. 2017Blood AdvancesSelf Cite353311Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Using an allo-SCT-induced model of lung injury, we have previously demonstrated the importance of IL-6 in driving Th17 development. 2 Here, we also observed Th17 differentiation to be highly dependent upon IL-6R signaling in all tissues examined ( Figure 1C). IL-17A expression was transient such that the proportion of CD4…”Section: Yfpmentioningconfidence: 56%“…Although calcineurin inhibition is known to have broad immunosuppressive effects on T-cell responses, including a significant reduction in overall Th17 frequencies, 2 we found that CsA treatment successfully reduced the transition of IL-17A 1 IFNg -Th17 toward an IFNg2producing phenotype ( Figure 4A-B). Because we have previously demonstrated that donor antigen-presenting cells (APCs) are a major source of IL-12 posttransplant, 37 we examined the effect of CsA using IL-12p40-YFP reporter mice. …”Section: Relative Expressionmentioningconfidence: 76%“…2,36 Therefore, we assessed the influence of CsA treatment on Th17 cytokine plasticity by exposing mice to increasing doses of CsA …”Section: Inflammatory Th17 Are Regulated By Immunosuppression In Bothmentioningconfidence: 99%“…This effect is perhaps most prominent in interleukin-17 (IL-17)-producing donor T cells, which we and others have shown to be highly pathogenic in preclinical models of GVHD. [1][2][3][4][5][6] Plasticity has been widely reported in CD4 IL-17A 1 (Tc17) T cells in a range of infectious and autoimmune settings. [6][7][8][9][10][11][12] We have recently described Tc17 cytokine plasticity in murine allo-SCT recipients, 1 which is characteristic of a hyper-proinflammatory T-cell subset that contributes to GVHD but fails to mediate graft-versus-leukemia effects. …”Section: Introductionmentioningconfidence: 99%See 2 more Smart Citations

Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT

Gartlan1, Varelias2, Koyama3 et al. 2017Blood AdvancesSelf Cite353311Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Cutaneous pathology also may be generated by Th17 cells; although they are more commonly associated with chronic GVHD (cGVHD), they also have been associated with acute pathology (22)(23)(24). Th17 differentiation is initiated by IL-6 (25), and RORgt is the defining transcription factor (26), whereas maintenance and amplification relies on IL-23 and IL-21, respectively (27). …”Section: Cytokines and Acute Gvhdmentioningconfidence: 99%

Cytokines in Graft-versus-Host Disease (V体育官网入口)

Henden1, Hill2 2015The Journal of ImmunologySelf Cite16871261Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

Successful ruxolitinib administration for a patient with steroid‐refractory idiopathic pneumonia syndrome following hematopoietic stem cell transplantation: A case report and literature review

Tomomasa1, Isoda2, Mitsuiki3 et al. 2021Clinical Case Reports8010Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.