Resident memory T cells in human health and disease (VSports app下载)

V体育官网 - Fine-Needle Aspiration Biopsy of the Lymph Node: A Novel Tool for the Monitoring of Immune Responses after Skin Antigen Delivery

Tatović1, Young2, Kochba3 et al. 2015The Journal of Immunology192180Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…This reservoir is polyclonal and in contrast to the blood or lymph node (LN) contains almost exclusively T cells of memory phenotype (6). Recent studies are consistent with the view that these cells represent a very comprehensive and long-lived memory "library" not only of Ag exposure that has previously occurred in that area of skin but also of responses that have occurred elsewhere in the skin and probably in other epithelial barrier tissues as well (7). This is achieved by the generation of memory T cells with skin homing receptors during immune responses occurring at other locations, which recirculate to the skin all over the body and reside there for many years. …”mentioningconfidence: 53%

Fine-Needle Aspiration Biopsy of the Lymph Node: A Novel Tool for the Monitoring of Immune Responses after Skin Antigen Delivery

Tatović1, Young2, Kochba3 et al. 2015The Journal of Immunology192180Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The high proportion of influenzaspecific Trm cells in HLA-B57 individuals could reflect a difference among HLA-A-and HLA-B-restricted epitopes in developing into Trm cells or could possibly reflect an enhanced capacity of HLA-B57 individuals to form Trm cells VSports app下载. It is noteworthy that the HLA-B57 allele is highly associated with drug-induced inflammatory disease of the skin and with the development of psoriasis; both of these conditions have been recently linked to skin-resident memory T cells (22)(23)(24). Further studies and a larger cohort of clinical samples are required before such an association between HLA type and Trm cell development can be made. …”Section: Discussionmentioningconfidence: 99%

"VSports" Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles

Pizzolla1, Nguyen2, Sant3 et al. 2018Journal of Clinical Investigation172111821Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…Evaluation of TSLP protein levels across biopsy specimens in a blinded manner revealed that lesional keratinocytes in the calcipotriol plus 5-FU group had significantly higher TSLP expression levels than did those in the Vaseline plus 5-FU group (P <0. 0001, Supplemental Table 5). A large number of HLA-DP-DQ-DR + antigen-presenting The quick appearance of inflammation and its delayed peak in the calcipotriol plus 5-FU group suggest that both the activation of tissue-resident T cells (26) and the recruitment of naive circuiting T cells contributed to the observed antitumor immune response. The extent of the inflammation on the forehead and temples of the calcipotriol plus 5-FU-treated participants suggests an extension of T cell immunity against highly mutated but normal-appearing skin on chronically sun-damaged skin (27). …”Section: Discussionmentioningconfidence: 99%

Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy (V体育官网入口)

Cunningham1, Tabacchi2, Eliane3 et al. 2016Journal of Clinical Investigation16531591Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.