A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing

"VSports最新版本" The diverse role of RIP kinases in necroptosis and inflammation

Silke1, Rickard2, Gerlic3 2015Nat Immunol479744801Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…3), probably because of a conformational change induced in RIPK3 that allows it to activate caspase-8 via RIPK1. Similarly, a study has suggested that wild-type RIPK3 may undergo a similar conformation change to induce TRIF-dependent activation of caspase-8 and processing and secretion of IL-1b 83 . This effect clearly limits the potential utility of RIPK3 kinase inhibitors in blocking cell large number of neutrophils and high levels of inflammation, Ripk1 -/-and Ripk1 -/-Casp8 -/-mice have this active cleaved form of IL-33 in their plasma, but Ripk1 -/-Ripk3 -/-and Ripk1 -/-Mlkl -/-mice do not. …”Section: Evidence For Necroptotic Dampsmentioningconfidence: 99%

The diverse role of RIP kinases in necroptosis and inflammation

Silke1, Rickard2, Gerlic3 2015Nat Immunol479744801Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…These noninflammasome platforms for caspase-8 variously include TRIF, RIP1, FADD, and in some cases RIP3 (42). It is important to note that caspase-8 physiologically acts as the predominant IL-1␤-processing enzyme in these noninflammasome stimulus models despite the expression of normal procaspase-1 levels. …”Section: Discussionmentioningconfidence: 99%“…Multiple studies have described a role for caspase-8 as a major IL-1␤-processing enzyme downstream of ASC/ inflammasome-independent signaling complexes assembled when DCs or macrophages are costimulated with TLR4/TLR3 agonists and a variety of extrinsic or intrinsic cell stressors (8,12,15,17,21,42). These noninflammasome platforms for caspase-8 variously include TRIF, RIP1, FADD, and in some cases RIP3 (42). …”Section: Discussionmentioningconfidence: 99%

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

Antonopoulos1, Russo2, Sanadi3 et al. 2015Journal of Biological Chemistry207111642Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Importantly, RIPK1, RIPK3, and MLKL have also been implicated in the activation of supramolecular complexes commonly known as inflammasomes, which are responsible for the CASP1-dependent maturation and secretion of interleukin 1 beta (IL1B) and IL18 (50–54). The precise mechanisms underlying inflammasome activation by core components of the necroptotic machinery remain a matter of debate. …”Section: Molecular Mechanisms Of Necroptosismentioningconfidence: 99%

VSports app下载 - Necroptosis: Mechanisms and Relevance to Disease

Galluzzi1, Kepp2, Chan3 et al. 2017Annu. Rev. Pathol. Mech. Dis. Self Cite64124930Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD VSports app下载. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.