HPV‐negative carcinoma of the uterine cervix: a distinct type of cervical cancer with poor prognosis (V体育2025版)

Using novel biomarkers to triage young adult women with minor cervical lesions: a cost‐effectiveness analysis

Pedersen1, Sørbye2, Kristiansen3 et al. 2016BJOG6190Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Squamous cell carcinoma is most the common (accounting for 70-80% of all CCs) and is the type that is most readily prevented by screening [2]. Although a persistent infection with HPV has been established as the necessary cause of CC, recent evidence suggest that a small proportion of CCs (predominantly adenocarcinomas) are not HPV-positive, even in studies that applied the most sensitive detection methods [24]. …”Section: Finally Invasive CC (International Classification Of Diseasmentioningconfidence: 99%“…This becomes even more important as CC screening transitions to involve primary HPV-testing, which is expected to be more effective in preventing cervical adenocarcinoma than cytologybased screening [2,41]. Furthermore, although HPV has been established as a causal agent of CC, emerging studies indicate that a proportion of CC cases are HPV-negative, and that this is relatively more common in adenocarcinomas than in squamous cell carcinomas [24]. In addition, some of the uncertainties regarding the causal web of CC (see Section 2. 1), such as the impact of smoking and other behavioral factors, is not captured explicitly by the model, but is inherently captured in the calibration targets (e. g. , HPV prevalence) and thus reflected in the incidence and progression rates. …”Section: Model Input Parameters and Assumptionsmentioningconfidence: 99%

Using novel biomarkers to triage young adult women with minor cervical lesions: a cost‐effectiveness analysis

Pedersen1, Sørbye2, Kristiansen3 et al. 2016BJOG6190Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Although there has been much evidence on the role of HPV in cervical precursor lesions and invasive cancer, it remains controversial how they affect prognosis of cervical cancer. Most studies have suggested that HPV-negative cervical cancer carried a poorer prognosis than HPV-positive [5][6][7]. However, some studies showed that HPV DNA did not have any prognostic implication [8,9]. …”Section: Introductionmentioningconfidence: 99%

Low Necroptosis Process Predicts Poor Treatment Outcome of Human Papillomavirus Positive Cervical Cancers by Decreasing Tumor-Associated Macrophages M1 Polarization

Li1, Yu2, Zang3 2018Gynecol Obstet Invest250261Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Although the PCR-based methods seem to be one of the most sensitive, several cases of CC remain HPV negative after re-analysis, and it has been suggested that this subset of tumors could represent a more aggressive group (Rodríguez-Carunchio, 2015). Similar results were found for head and neck (H&N) tumors (Liu, 2017) and anal cancer (Mai, 2015). …”Section: Introductionmentioningconfidence: 66%“…Concerning most prevalent genotypes HPV16/18, several studies have shown that patients with HPV18-containing tumors were at increased risk of death and disease recurrence, especially in early stage disease (Schwartz, 2001;Kang, 2011;Yang, 2014), while for Pilch et al HPV16 genotype had an independent negative impact on overall survival in 204 patients with CC (Pilch, 2001 (Riou, 1990;Lai, 2013;Rodríguez-Carunchio, 2015;Okuma, 2016 (Cuschieri, 2014). In the same way, two studies conducted in Chinese women, where most prevalent HPV genotypes are HPV16, 18, 52 and 58, did not find significant association between OS and infection with a particular HPV type, except for a slightly trend to better survival in HPV58 single-infected patients found by Shah et al (Lau, 2015;Shah, 2009 (Liu, 2017). …”Section: Discussionmentioningconfidence: 99%

Prevalence and Distribution of High-Risk Human Papillomavirus Genotypes in Invasive Carcinoma of the Uterine Cervix in Uruguay. An update on clinical outcome

Berois1, Nozar2, Greif3 et al. 2017MRAJ0000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC) VSports app下载. Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.