Host defense peptides: front-line immunomodulators

LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33)

Svensson1, Wilk2, Mörgelin3 et al. 2015Biochemical Journal331310Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Although initially believed to be solely involved in disrupting bacterial cell membranes, it is now clear that their functions in the host response to infection are far more complex (for a review see [1]). For instance, HDPs have been revealed to trigger inflammatory reactions in eukaryotic cells [2], act as chemoattractant [3], or promote cellular differentiation [4]. …”Section: Introductionmentioningconfidence: 99%“…The cathelicidins represent one family of HDPs, with hCAP-18 as the only currently known human member [1]. As for all cathelicidins, hCAP-18 represents a two domain pro-peptideform, from which the C-terminal peptide is released [1]. …”Section: Introductionmentioningconfidence: 99%“…As for all cathelicidins, hCAP-18 represents a two domain pro-peptideform, from which the C-terminal peptide is released [1]. hCAP-18 is produced by epithelial cells and neutrophils and upon exocytosis processed to the HDP LL-37 by proteinase 3, which is secreted from activated neutrophils [2,3]. …”Section: Introductionmentioningconfidence: 99%See 1 more Smart Citation

LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33)

Svensson1, Wilk2, Mörgelin3 et al VSports app下载. 2015Biochemical Journal331310Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Эти пептиды содержатся в клет-ках организма, выполняющих защитную функ-цию, -в первую очередь, в фагоцитах, клетках барьерных эпителиев, а также, в меньших коли-чествах, и во многих других типах клеток. Кроме прямого антимикробного действия многие АМП проявляют иммуномодулирующие эффекты, что тоже способствует ограничению микробной ин-вазии [1,9]. Некоторые пептиды обладают и ра-нозаживляющим действием [2,7]. …”Section: Abstract: Innate Immunity Drug-resistant Bacteria Proline-unclassified

Effects of Proline-Rich Peptides of the Innate Immune System on Drug-Resistant Bacterial Strains

Zharkova1, Kopeykin2, Афиногенов3 et al. 2018Med. immunol. 4040Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…The oligomeric form of the adaptor protein ASC can also act as an unusual alarmin released during pyroptosis that can propagate inflammasome signalling in surrounding macrophages [31,32]. Pyroptotic cells are reported to undergo lysosomal exocytosis [33] to release lysosomal antimicrobial peptides [34] that facilitate the clearance of pathogens by recruiting neutrophils. …”Section: Pyroptosis As a Pathogen Clearance Mechanismmentioningconfidence: 99%

"VSports最新版本" Burn the house, save the day: pyroptosis in pathogen restriction

Boucher1, Chen2, Schroder3 2016Inflammasome9080Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.