Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice (V体育官网)

CLCA2 epigenetic regulation by CTBP1, HDACs, ZEB1, EP300 and miR‐196b‐5p impacts prostate cancer cell adhesion and EMT in metabolic syndrome disease

Porretti1, Dalton2, Massillo3 et al. 2018Intl Journal of CancerSelf Cite362300Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…PC3 (ATCC: CRL‐1435), 22Rv1 (ATCC: CRL‐2505), LNCaP (ATCC: CRL‐1740), C4‐2 cell lines and its stable derivatives were grown in RPMI 1640 (Invitrogen) supplemented with 10% of fetal bovine serum (FBS) and antibiotics in a 5% CO 2 humidified atmosphere at 37°C. PC3. shCTBP1 and its control (PC3. pGIPZ) stable cell lines were described previously . PC3. shCLCA2 (shCLCA2) and its control PC3. pGIPZ (pGIPZ) cells lines were generated by lentiviral infection as described previously using pGIPZ. shCLCA2 or pGIPZ plasmids. …”Section: Methodsmentioningconfidence: 99%“…CTBP1 is a transcriptional co‐repressor of tumor suppressor genes that is activated with much higher affinity by NADH (>100‐fold) compared to NAD + . Therefore, we generated a MeS mice model by chronically feeding animals with a high fat diet (HFD) and found that CTBP1 depletion in MeS mice dramatically decreased PCa growth …”Section: Introductionmentioningconfidence: 99%

CLCA2 epigenetic regulation by CTBP1, HDACs, ZEB1, EP300 and miR‐196b‐5p impacts prostate cancer cell adhesion and EMT in metabolic syndrome disease

Porretti1, Dalton2, Massillo3 et al. 2018Intl Journal of CancerSelf Cite362300Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Following these early studies, CtBP1 overexpression has been observed in a number of different cancers, including prostate (64, 68), melanomas (69), colon (70), leukemia (71–73), ovarian (74, 75), and breast cancer (76, 77), among others VSports app下载. In most cases CtBP1 overexpression is pro-tumorigenic. …”Section: The Ctbp Co-repressors Play Multiple and Context-dependent Rmentioningconfidence: 97%“…Consistent with these findings, elevated NADH levels under hypoxic conditions associated with solid tumors repress the transcription of the CtBP target gene, E-cadherin, and increases cell migration, both of which are reversed by CtBP knockdown (23). Furthermore, increased NADH levels resulting from high-caloric intake, promotes both prostate and breast carcinogenesis in a CtBP1-dependent manner in vivo (45, 64, 65). Since CtBP1 is the more commonly studied CtBP family member in cancer, the remainder of this review will focus on CtBP1, its known oncogenic roles, and the possibility of therapeutically targeting this protein. …”Section: The Ctbp Co-repressors Play Multiple and Context-dependent Rmentioningconfidence: 99%

The Role of CtBP1 in Oncogenic Processes and Its Potential as a Therapeutic Target

Blevins1, Huang2, Zhao3 2017Molecular Cancer Therapeutics8481210Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“……”Section: Application To the Prostate Cancer Datamentioningconfidence: 99%

"V体育2025版" Hierarchical Feature Selection Incorporating Known and Novel Biological Information: Identifying Genomic Features Related to Prostate Cancer Recurrence

Zhao1, Chung2, Johnson3 et al. 2016Journal of the American Statistical Association230150Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Scite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.