"V体育官网" Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease

Ruxolitinib for treatment of refractory hemophagocytic lymphohistiocytosis

Broglie1, Pommert2, Rao3 et al. 2017Blood Advances1211880Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Recent data support the efficacy of ruxolitinib in reducing the symptoms of proinflammatory diseases including rheumatoid arthritis, ulcerative colitis, myeloproliferative disorders, psoriasis, and graft-versus-host disease. 6,7,[15][16][17][18][19][20][21][22] In murine models, ruxolitinib has been shown to both prevent and treat HLH by decreasing cytokine production and inflammation via inhibition of STAT1 signaling. 4,5 There is an active trial using ruxolitinib in adults with secondary HLH, but there have been no reports of pediatric patients who have received ruxolitinib for the treatment of HLH. …”Section: Resultsmentioningconfidence: 99%

Ruxolitinib for treatment of refractory hemophagocytic lymphohistiocytosis

Broglie1, Pommert2, Rao3 et al. 2017Blood Advances1211880Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…50 Conversely, JAK inhibitors appear to reduce acute GVHD in murine models by increasing T-regulatory cells, which has led to the successful treatment of six patients with ruxolitinib for steroidrefractory acute GVHD. 51 Another JAK inhibitor, tofacitinib, a selective JAK3 inhibitor, has been found to reverse CD8 + T-cellmediated mucocutaneous GVHD-like disease in a murine model. 52 IMPACT OF TARGETING THE EPIGENOME Studies on the remarkable complexity of genetic architecture in MPNs have discovered an unexpected degree of differences in individual cases at the epigenetic level. …”Section: Impact Of Targeting the Jak/signal Transducers And Activatormentioningconfidence: 99%

VSports手机版 - Allo-SCT for myelofibrosis: reversing the chronic phase in the JAK inhibitor era?

Tamari1, Mughal2, Rondelli3 et al. 2015Bone Marrow Transplant150122Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD VSports app下载. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Руксолитиниб также вызыва-ет супрессию многих провоспалительных цитокинов + Т-клеток через сигнальный путь STAT и по-вышает количество FoxP3 + Tregs, что также уменьшает клинические проявления РТПХ [80,81]. В Санкт-Пе-тербурге проводится клиническое исследование со-вместной эффективности руксолитиниба и ПТЦ для профилактики РТПХ при алло-ТГСК у больных миелофиброзом (NCT02806375) [82]. …”Section: гаплоидентичная трансплантация и профилактика реакции «трансunclassified

"V体育2025版" Allogeneic transplantation of hematopoietic stem cells: Perspectives and alternatives, own experience

Pop1, Рукавицын2 2017Ross. ž. det. gematol. onkol. 4000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Scite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.