Inhibition of mTOR Signaling Reduces PELP1-Mediated Tumor Growth and Therapy Resistance (V体育ios版)

The social network of PELP1 and its implications in breast and prostate cancers

Gonugunta1, Lu2, Sareddy3 et al. 2014Endocrine-Related Cancer220280Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC) VSports app下载. Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Patients whose tumors have high levels of cytoplasmic PELP1 respond poorly to tamoxifen therapy compared with patients whose tumors have low levels of cytoplasmic PELP1 (Kumar et al 2009). These observations are in agreement with results from an experiment in which tamoxifen-susceptible MCF-7 cells engineered to express PELP1 in cytosol (by modification the nuclear localization sequence) were found to exhibit resistance to tamoxifen , Kumar et al 2009, Gonugunta VK, Sareddy GR, Krishnan SR, Cortez V, Roy SS, Tekmal RR & Vadlamudi RK, 2014. The subcellular localization of PELP1 could be used as a biomarker of hormone sensitivity or vulnerability. …”Section: Pelp1 and Therapy Resistancesupportingconfidence: 89%

The social network of PELP1 and its implications in breast and prostate cancers

Gonugunta1, Lu2, Sareddy3 et al. 2014Endocrine-Related Cancer220280Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The activity of mTOR is essential to maintain cell growth and proliferation in the PI3K/AKTdependent pathway, as evidenced by the fact that inhibition of mTOR prevents cell proliferation and enhances the development of embryonic stem cells [27][28][29]. mTOR, a member of the phosphatidylinositol 3 kinase (PI3K) family, is a ubiquitously expressed serine/threonine kinase involved in cell growth, cellular nutrient, and protein stability. …”Section: Resultsmentioningconfidence: 99%

"VSports手机版" Oridonin inhibits mTOR signaling and the growth of lung cancer tumors

Wang1, Lv2, Lu3 et al. 2014Anti-Cancer Drugs332240Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…PELP1 also interacts with several kinases including c-Src (Chakravarty et al 2010a), phosphoinositide 3-kinase (PI3K) (Dimple et al 2008), epidermal growth factor receptor (EGFR) (Vadlamudi et al 2005c), integrin-linked kinase (ILK1) (Chakravarty et al 2010a), mechanistic target of rapamycin (mTOR) (Gonugunta et al 2014b) and GSK3β (Sareddy GR et al 2015). PELP1 interactions with cell cycle and growth factor signaling components suggest its potential role as a mediator of hormonal singling cross talk with cell cycle machinery. …”Section: Pelp1 Interactomementioningconfidence: 99%“…PELP1 modulates the ESR1–Src–ILK1 signaling to promote cytoskeletal rearrangements, motility and metastasis (Chakravarty et al 2010b). PELP1 also interacts with mTOR and activates its downstream signaling (Gonugunta et al 2014b). …”Section: Biological Functions Of Pelp1mentioningconfidence: 99%“…Results from these studies supported that inhibition of CDK2 activity has the potential to abrogate the growth of PELP1-driven, hormonal therapy–resistant cells (Nair et al 2011). The mTOR-targeting drugs rapamycin and AZD8055 significantly reduced proliferation of PELP1-overexpressed breast cancer cells in both in vitro and in vivo xenograft tumor models, suggesting that mTOR inhibitor(s) may be effective chemotherapeutic agents for downregulating PELP1 oncogenic functions (Gonugunta et al 2014b), A recent study showed that liganded PR-B enhances the proliferative responses to estradiol and IGF1 via scaffolding of ESR1-PELP1-IGF1R-containing complexes. Therefore, PR antagonists may have therapeutic utility in treating a subset of PELP1-deregulated luminal ESR1, PR positive breast cancer (Daniel et al 2015). …”Section: Therapeutic Targeting Of Pelp1mentioningconfidence: 99%See 1 more Smart Citation

PELP1: Structure, biological function and clinical significance

Sareddy1, Vadlamudi2 2016GeneSelf Cite431650Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.