"V体育官网入口" Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

"V体育2025版" Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota

Wahlström1, Kovatcheva‐Datchary2, Ståhlman3 et al. 2017Journal of Lipid Research814530Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…Others have reported high levels of HDCA and no MCA in CONV-R mice (35), in contrast to our finding of predominantly MCA and very low levels of HDCA in mice colonized with mouse microbiota. Variations in the microbiota community between different mouse facilities might explain these discrepancies because specific bacteria possess different abilities to generate these two secondary BAs (generation of HDCA from MCA requires both 7-dehydroxylation and 6-epimerization, whereas generation of MCA only requires 6-epimerization). …”Section: Discussioncontrastingconfidence: 56%

V体育平台登录 - Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota

Wahlström1, Kovatcheva‐Datchary2, Ståhlman3 et al. 2017Journal of Lipid Research814530Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…Treatment of mice with probiotics resulted in enhanced deconjugation and fecal excretion of BAs, affecting ileal BA absorption and subsequent stimulation of hepatic de novo BA synthesis via repression of the enterohepatic FXR-FGF15/FGF19-FGFR4 pathway [56] VSports app下载. Hara and coworkers reported that obesity induced changes of the gut microbiota, leading to increased levels of the secondary BA DCA in the enterohepatic circulation. …”Section: Ba In Health and Diseasementioningconfidence: 99%

Bile acids in drug induced liver injury: Key players and surrogate markers

Schadt1, Wolf2, Pognan3 et al. 2016Clinics and Research in Hepatology and Gastroenterology731540Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…For example, microbiota effects upon body weight, adiposity, lipid metabolism, liver disease, intestinal mucosal function, colon carcinogenesis, and cardiovascular function have recently been linked to luminal bile acid metabolism and modulation of bile acid signaling ( 26, 213-218 ). Of note, these studies are at the forefront of a new fi eld, and make innovative use of mouse models with altered microbiomes, including models that are germ-free or colonized with specifi c organisms, including microbiota from humans with select clinical characteristics ( 214,216,(219)(220)(221)(222)(223)(224). Compared with mice raised conventionally, the pool of bile acids in germ-free mice is less "FXR agonistic," because the bile and luminal contents include an increased proportion of tauro-␤ -murocholic acid, an endogenous mouse bile acid species that functions as an FXR antagonist ( 26, 223 ). …”Section: Consequences Of Intestinal Bile Acid Metabolism On Bile Acidmentioningconfidence: 99%

V体育2025版 - Intestinal transport and metabolism of bile acids

Dawson1, Karpen2 2015Journal of Lipid Research52544631Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Scite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.