Shuttling of information between the mucosal and luminal environment drives intestinal homeostasis

V体育官网 - Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome

Weber1, Oefner2, Hiergeist3 et al. 2015Blood18581670Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…3,24 Thus, early loss of bacteria of these genera may result in massive disruption of intestinal immunoregulation 25 and contribute to development of GVHD and associated complications. Interestingly, it is hypothesized that disruption of the microbiome by the use of antibiotics in the first months after birth may be responsible for the development of autoimmune disorders in children as microbiota shifts occur in a sensitive period of immune reconstitution. …”Section: 22mentioningconfidence: 99%

Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome

Weber1, Oefner2, Hiergeist3 et al. 2015Blood18581670Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…However, the mucus layer is not simply a static barrier to entry; goblet cells modulate their secretions in response to external stimuli. The best-characterized example is in the intestinal epithelium, where gut microflora and the mucus layer interact dynamically [6,94]. The intestines of germfree mice contain fewer goblet cells than normal mice, and maintain a thinner mucosal layer, whereas cholera toxin and listeria toxin, among other agents associated with infection, rapidly induce mucin production by goblet cells, highlighting the ability of goblet cells to respond to the needs of their mucosal environment [6,94]. …”Section: Reviewmentioningconfidence: 99%“…The best-characterized example is in the intestinal epithelium, where gut microflora and the mucus layer interact dynamically [6,94]. The intestines of germfree mice contain fewer goblet cells than normal mice, and maintain a thinner mucosal layer, whereas cholera toxin and listeria toxin, among other agents associated with infection, rapidly induce mucin production by goblet cells, highlighting the ability of goblet cells to respond to the needs of their mucosal environment [6,94]. Upregulation of goblet cells and mucus production is a crucial response to harmful stimuli in mucosal epithelium, and is accomplished in response to a wide variety of proinflammatory cytokines [6]. …”Section: Reviewmentioningconfidence: 99%

VSports手机版 - Three cheers for the goblet cell: maintaining homeostasis in mucosal epithelia

McCauley1, Guasch2 2015Trends in Molecular Medicine20751490Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The gastrointestinal barrier is primarily composed of intestinal epithelial cells (IECs) and their soluble products (2). IECs also participate in inflammatory responses directly through processes such as autophagy and indirectly through the production of cytokines that recruit innate and adaptive immune cells to sites of mucosal damage (3). The proteins found in the cytosol and released from IECs during inflammation include high-mobility group box 1 (HMGB1). …”Section: Introductionmentioningconfidence: 99%

Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation

Zhu1, Messer2, Wang3 et al. 2015J. Clin. Invest. 18851520Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC) VSports app下载. Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Scite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.