HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs (VSports最新版本)

Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis

Nagaraju1, Bramhachari2, Raghu3 et al. 2015Cancer Letters1150801Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…Several reports have shown that ROS mediates the stabilization of HIFα in hypoxic conditions [46][47][48] and destabilization in normoxic conditions [49][50][51]. ROS also stabilizes HIF1α in metastatic cancer cells, which in turn reprograms the cells by decreasing cytotoxic ROS levels, leading to further metastasis [52]. ROS is known to oxidize Fe +2 to Fe +3 ; this may lead to declined activity of PHDs and accumulation of HIF1α. …”Section: Mitochondria In Hifα Stabilizationmentioningconfidence: 96%“…Circulating cancer cells recruited to the lungs demonstrate an increase in intracellular ROS levels that lead to HIF1α stability. The ROS-stabilized HIF1α shifts cell metabolism from aerobic to anaerobic glycolysis by phosphorylating pyruvate dehydrogenase E1 alpha subunit (PDH-E1α), inhibiting pyruvate dehydrogenase activity and increasing the expression of lactate dehydrogenase A (LDHA) [52]. This vicious cycle promotes tumor metastasis and growth. …”Section: Mitochondria In Hifα Stabilizationmentioningconfidence: 99%

Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis

Nagaraju1, Bramhachari2, Raghu3 et al. 2015Cancer Letters1150801Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…For example, HIF-1 activity is transiently increased during metastasis due to high ROS levels (Montagner et al 2012;Zhao et al 2014). HIF-1 activation metabolically reprograms metastasizing cells away from oxidative phosphorylation to glycolysis and lactic acid production, through increased expression of lactate dehydrogenase and pyruvate dehydrogenase. …”Section: Cancer Cells Undergo Metabolic Changes To Manage Rosmentioningconfidence: 99%

Cancer, Oxidative Stress, and Metastasis

Gill1, Piskounova2, Morrison3 2016Cold Spring Harb Symp Quant Biol25531980Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Lower levels of mitochondrial ROS (mtROS) play important roles as signaling molecules to adapt to stress and are required for normal cell homeostasis, while excessive quantities of mtROS directly damage proteins, lipids and nucleic acids, and lead to cell death (21). Previous reports have shown that HIF-1α is also stabilized by mtROS, whereby mtROS inactivate PHDs by decreasing intracellular Fe 2+ levels through oxidization to Fe 3+ (24)(25)(26)(27). Macroautophagy (general autophagy) is a dynamic process through which cytosol and organelles are sequestered into a double-membrane vesicle called an autophagosome and delivered to the lysosome for breakdown and recycling during challenging conditions, such as nutrient depletion or hypoxia. …”Section: Introductionmentioningconfidence: 99%

VSports app下载 - Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia

Shida1, Kitajima2, Nakamura3 et al. 2016International Journal of Oncology576310Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.