The role of iron and reactive oxygen species in cell death

Ferroptosis: process and function

Xie1, Hou2, Song3 et al. 2016Cell Death Differ3,288522,6753Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…20 In addition, activation of the mitogen-activated protein kinase (MAPK) pathway contributes to ferroptotic cancer cell death. …”Section: Signaling Pathwaymentioningconfidence: 99%

Ferroptosis: process and function

Xie1, Hou2, Song3 et al. 2016Cell Death Differ3,288522,6753Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Interestingly, not all triggers that initiate Fenton reactions in lysosomes cause ferroptosis (Dixon et al, 2012). This further suggests that ironcatalyzed ROS from lysosomes are dispensable drivers of ferroptosis (Dixon and Stockwell, 2014). In addition, it was shown that ferroptosis was not affected by the broad spectrum cysteine cathepsin inhibitor E64d implying that lysosomal cysteine cathepsins are neither critical for ferroptotic cell death (Dixon et al, 2012). …”Section: Ferroptosis and Oxytosismentioningconfidence: 93%“…Oxytosis was initially described as oxidative glutamate-induced death of neuronal cells (Tan et al, 2001;Dixon and Stockwell, 2014). Similar to ferroptosis, oxytosis also relies on the prevention of cysteine uptake by the XC-cysteine/glutamine antiporter. …”Section: Ferroptosis and Oxytosismentioningconfidence: 99%“…This allows an increase in Fenton generated ROS and subsequently major lipid damage. The critical factor in ferroptosis is most likely antioxidant insufficiency (Dixon et al, 2012;Dixon and Stockwell, 2014). As described above, lysosomes are important cellular pools of redox-active iron and their biochemistry creates an excellent environment for Fenton reactions (Kurz et al, 2011). …”Section: Ferroptosis and Oxytosismentioningconfidence: 99%See 1 more Smart Citation

Lysosomes in programmed cell death pathways: from initiators to amplifiers

Kavčič1, Pegan2, Turk3 2016Biological Chemistry660300Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Reactive oxygen species (ROS), was a blanket term for a collection of partially reduced oxygen containing molecules, including superoxide (O 2 À ), peroxides (H 2 O 2 and ROOH) and free radicals (HO and RO ) (Dixon and Stockwell, 2014). Certain amounts of ROS were crucial for normal cell and organismal function (Dröge, 2002 ROS was linked to the damage of biological macromolecule, such as DNA, proteins (enzymes), and lipids (membrane) etc. …”Section: Introductionmentioningconfidence: 99%

Effects of pyrogallic acid on Microcystis aeruginosa: oxidative stress related toxicity

Lu1, Zhang2, Gao3 et al. 2016Ecotoxicology and Environmental Safety57090Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC) VSports app下载. Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Scite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.