"VSports手机版" GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity

Mediastinal and Disseminated Mycobacterium kansasii Disease in GATA2 Deficiency (VSports在线直播)

Lovell1, Zerbe2, Olivier3 et al. 2016Annals ATSSelf Cite130100Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC) VSports app下载. Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In contrast, patients with GATA2 deficiency develop disseminated disease beginning in their early 20s. The levels of B, NK, and CD4 1 T cells, and of monocytes, are variable in GATA2 deficiency; however, infectious complications increase as cytopenias evolve, which typically begins in late adolescence or adulthood (11). The absence of disseminated M. kansasii disease in childhood likely results from intact T-cell and monocyte compartments in GATA2 deficiency early in life. …”Section: Discussionmentioningconfidence: 99%“…GATA2 is a transcription factor required for the differentiation and proliferation of hematopoietic stem cells (HSCs). Deficiency of GATA2 contributes susceptibility to severe and disseminated viral (e. g. , human papillomavirus), fungal, and NTM infections, pulmonary alveolar proteinosis, and myelodysplastic syndrome (MDS) (11). The hematologic profile of patients includes deficiencies of NK cells, monocytes, and B cells, and down-regulation of GATA2 has also been associated with impaired phagocytic activity of alveolar macrophages (12). …”mentioningconfidence: 99%

Mediastinal and Disseminated V体育官网 - Mycobacterium kansasii Disease in GATA2 Deficiency

Lovell1, Zerbe2, Olivier3 et al. 2016Annals ATSSelf Cite130100Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Overall, non-curative therapies should be limited and because of the high risk for evolution of advanced MDS with unfavorable karyotypes, timely HSCT should be suggested as a curative approach. Overall survival (OS) of GATA2-mutated patients transplanted for immunodeficiency was shown to be 54% at 4 years after transplantation in a NIHbased study [23]. In pediatric GATA2 cohorts, 5-year OS was 66% in patients transplanted for MDS with monosomy 7. …”Section: Treatment Of Myeloid Neoplasms With Germline Gata2 Mutationsmentioningconfidence: 99%“…Generalized warts related to HPV infection were common viral complication, in addition to severe HSV, VZV, EBV and CMV infections. Disseminated non-tuberculous mycobacteria (NTM) infections were observed in about half of cases with MonoMAC syndrome [23]. Severe bacterial or fungal infections, and pulmonary alveolar proteinosis (PAP) were also prevalent in MonoMAC syndrome. …”Section: Monomac Syndrome/dcml Deficiencymentioningconfidence: 99%“…GATA2 protein is expressed at high levels in endothelial cells and lymphatic vessel valves [26,27] and controls the expression of PROX1 and FOXC2 genes important for programming lymphatic valve development [28]. In one study, it has been suggested that N-terminal frameshift mutations or larger deletions of GATA2 are more likely to cause lymphedema [23]; however, this association could not be confirmed in other patient cohorts [6]. Congenital deafness is presumed to result from failure of generation of the perilymphatic space surrounding the semicircular ducts in inner ear [29]. …”Section: Emberger Syndromementioningconfidence: 99%See 1 more Smart Citation

V体育平台登录 - Heterogeneity of GATA2-related myeloid neoplasms

Hirabayashi1, Włodarski2, Kozyra3 et al. 2017Int J Hematol560500Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Hereditary Cancer Syndromes: Risk Assessment and Genetic Counseling

Webster1, Bannon2, Hyde3 et al. 2019Holland‐Frei Cancer Medicine0000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.