"VSports" Aldehyde Dehydrogenase Expression Drives Human Regulatory T Cell Resistance to Posttransplantation Cyclophosphamide

Erratum: Modern approaches to HLA-haploidentical blood or marrow transplantation.

Kanakry1, Fuchs2, Luznik3 2015Nat Rev Clin OncolSelf Cite750280Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…115 Donor T cells exposed to host antigens on day 0 were largely depleted, whereas non-alloreactive donor T cells, which divided more slowly in a lymphopenic environment, were relatively spared. 115 However, destruction of alloreactive donor T cells was necessary but not sufficient for PTCy-induced tolerance: in mouse models of MHCmatched alloBMT in which donor CD4 + T cells promote GVHD, as well as in xenograft models, donor T REG cells were necessary to prevent lethal GVHD after PTCy treatment, 116,117 an effect consistent with the results from skin allograft models. Donor T REG cells in both mouse and human models of alloBMT were resistant to PTCy-induced cytotoxicity owing to increased expression of aldehyde dehydrogenase, the enzyme primarily responsible for in vivo detoxification of cyclophosphamide, 118 upon alogeneic stimulation in a lymphopenic environment. …”Section: Post-transplantation Cyclophosphamide Biological and Preclinsupportingconfidence: 71%

Erratum: Modern approaches to HLA-haploidentical blood or marrow transplantation.

Kanakry1, Fuchs2, Luznik3 2015Nat Rev Clin OncolSelf Cite750280Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Post-transplant Cy is an effective strategy for GVHD prevention with reduced impairment in immune reconstitution that is observed with more profound T-cell depletion strategies previously used in haploidentical HSCT. 27,31 In our small series, the rate of acute and chronic GVHD was low, and only one patient developed severe GVHD that needed secondary systemic therapy. The use of post transplant Cy for GVHD prophylaxis during haploidentical HSCT has been associated with relatively high rates of relapse in patients with hematologic malignancies, probably because of mitigation of the GVL effect. …”Section: Discussionmentioningconfidence: 65%

VSports最新版本 - Haploidentical BMT and post-transplant Cy for severe aplastic anemia: a multicenter retrospective study

Esteves1, Bonfim2, Pasqüini3 et al. 2015Bone Marrow Transplant14411142Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…16 Furthermore, CD4(+)CD45RA(− )Foxp3 (+hi) effector regulatory T cells express high levels of aldehyde dehydrogenase and appear to readily survive the use of high-dose CY and may contribute to the prevention of GVHD following Haplo-post-HCT-CY. 17 Based upon some of these observations, the group at Johns Hopkins University translated this approach into a clinical protocol of HaploD transplantation using a non-myeloablative conditioning regimen (pre-transplant fludarabine (150 mg/m 2 ), CY (29 mg/kg) and 2 Gy TBI, a T-replete BM graft followed by ptCY (50 mg/kg on d+3), MMF (day 4 to 35) and tacrolimus (day 4 to >50). 18 They demonstrated that donor engraftment without severe GVHD occurred in eight of ten patients treated on this regimen. …”Section: Use Of Post-transplant Cy To Selectively Control Allo-reactimentioningconfidence: 99%

"VSports" T-cell replete haploidentical donor transplantation using post-transplant CY: an emerging standard-of-care option for patients who lack an HLA-identical sibling donor

Bashey1, Solomon2 2014Bone Marrow Transplant751512Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.